CASP5 - Caspase-5 - human protein (Function)
 
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CASP5 »  Caspase-5   [ EC 3.4.22.58 ]  (CASP-5)
 
Protein also known as:  Protease ICH-3. Cleaved into:  Caspase-5 subunit p10; Caspase-5 subunit p20.
Gene name:  CASP5
Family name: Peptidase C14A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Mediator of programmed cell death (apoptosis).  
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  • UniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
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  • RefGenome
Cysteine-type peptidase activitydefinition[GO:0008234]  
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  • PINC
GO biological process 
Apoptotic processdefinition[GO:0006915]  
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  • PINC
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • UniProtKB
Execution phase of apoptosisdefinition[GO:0097194]  
1
  • RefGenome
Proteolysisdefinition[GO:0006508]  
1
  • UniProtKB KW
Regulation of apoptotic processdefinition[GO:0042981] silver  
1
  • InterPro 2 GO
Regulation of inflammatory responsedefinition[GO:0050727]  
1
  • RefGenome
Substantia nigra developmentdefinition[GO:0021762]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.58: Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
NOD-like receptor signaling pathway  hsa04621+838  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P51878
Other
GenomeRNAi: 838
PRO: PR:P51878
Chemistry
GuidetoPHARMACOLOGY: 1621