NEK4 - Serine/threonine-protein kinase Nek4 - human protein (Function)
 
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NEK4 »  Serine/threonine-protein kinase Nek4   [ EC 2.7.11.1 ]
 
Protein also known as:  Serine/threonine-protein kinase NRK2.
Gene name:  NEK4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 3
GENE REF ISO

Function

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Overview 
Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.  
3
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Manganese ion bindingdefinition[GO:0030145]  
1
  • Ortholog Curator
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • Ortholog Curator
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702]  
1
  • RefGenome
GO biological process 
Cell divisiondefinition[GO:0051301]  
1
  • UniProtKB KW
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • UniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
1
  • RefGenome
Mitotic cell cycledefinition[GO:0000278]  
1
  • UniProtKB
Mitotic nuclear divisiondefinition[GO:0007067]  
1
  • UniProtKB KW
Positive regulation of transcription, DNA-templateddefinition[GO:0045893] silver  
1
  • CACAO
Protein phosphorylationdefinition[GO:0006468]  
1
  • Ortholog Curator
Regulation of cellular senescencedefinition[GO:2000772]  
1
  • UniProtKB
Regulation of replicative cell agingdefinition[GO:1900062]  
1
  • UniProtKB
Regulation of response to DNA damage stimulusdefinition[GO:2001020] silver  
1
  • CACAO
Signal transduction by protein phosphorylationdefinition[GO:0023014]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
2
  • UniProtKB
It requires the following cofactor
 Mn(2+)  
2
  • UniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Mitosis  definition   [KW-0498]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 6787
PRO: PR:P51957
Chemistry
GuidetoPHARMACOLOGY: 2119