FUT6 - Alpha-(1,3)-fucosyltransferase 6 - human protein (Function)
 
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Protein
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References

 
FUT6 »  Alpha-(1,3)-fucosyltransferase 6
 
Gene name:  FUT6
Family name: Glycosyltransferase 10
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 25 2
GENE REF ISO

Function

 show evidences
Overview 
Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.  
  • CuratedUniProtKB
GO molecular function 
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activitydefinition[GO:0017060]  
  • IEAEC 2 GO
Alpha-(1->3)-fucosyltransferase activitydefinition[GO:0046920]  
1
  • TASUniProtKB
Fucosyltransferase activitydefinition[GO:0008417]  
1
  • TASPINC
GO biological process 
Fucosylationdefinition[GO:0036065]  
2
  • TASGOC
  • IEAInterPro 2 GO
  • IEAEC 2 GO
L-fucose catabolic processdefinition[GO:0042355]  
1
  • NASUniProtKB
Protein glycosylationdefinition[GO:0006486]  
1
  • TASUniProtKB
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.65: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 10  GT10  
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycosphingolipid biosynthesis - lacto and neolacto series  hsa00601+2528  
Metabolic pathways  hsa01100+2528  
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FUT6
GenomeRNAi: 2528
PRO: PR:P51993