PGD - 6-phosphogluconate dehydrogenase, decarboxylating - human protein (Function)
 
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Protein
Gene
References

 
PGD »  6-phosphogluconate dehydrogenase, decarboxylating   [ EC 1.1.1.44 ]
 
Gene name:  PGD
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity).  
  • CuratedUniProtKB
GO molecular function 
NADP bindingdefinition[GO:0050661] silver  
  • IEAInterPro 2 GO
Phosphogluconate dehydrogenase (decarboxylating) activitydefinition[GO:0004616]  
  • ISSOrtholog Curator
GO biological process 
D-gluconate metabolic processdefinition[GO:0019521]  
  • IEAUniProtKB KW
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDAUniProtKB
Pentose biosynthetic processdefinition[GO:0019322] silver  
  • IEAOrtholog Compara
Pentose-phosphate shuntdefinition[GO:0006098]  
  • ISSOrtholog Curator
Pentose-phosphate shunt, oxidative branchdefinition[GO:0009051]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.44: 6-phospho-D-gluconate + NADP(+) D-ribulose 5-phosphate + CO(2) + NADPH.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glutathione metabolism  hsa00480+5226  
Metabolic pathways  hsa01100+5226  
Pentose phosphate pathway  hsa00030+5226  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 

Keywords

Biological process 
Gluconate utilization  definition   [KW-0311]
Pentose shunt  definition   [KW-0570]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P52209
Other
GenomeRNAi: 5226
PRO: PR:P52209