JAK3 - Tyrosine-protein kinase JAK3 - human protein (Function)
 
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JAK3 »  Tyrosine-protein kinase JAK3   [ EC 2.7.10.2 ]
 
Protein also known as:  Leukocyte janus kinase (L-JAK).
Gene name:  JAK3
Entry whose protein(s) existence is based on evidence at protein level
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1 145 3
GENE REF ISO

Function

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Overview 
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.  
4
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
  • IEAEC 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • IPIUniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713]  
  • ISSOrtholog Curator
GO biological process 
B cell differentiationdefinition[GO:0030183]  
  • ISSOrtholog Curator
Enzyme linked receptor protein signaling pathwaydefinition[GO:0007167]  
  • ISSOrtholog Curator
Innate immune responsedefinition[GO:0045087]  
  • IEAUniProtKB KW
Interleukin-4-mediated signaling pathwaydefinition[GO:0035771]  
1
  • IDABHF-UCL
Intracellular signal transductiondefinition[GO:0035556]  
  • ISSOrtholog Curator
JAK-STAT cascade involved in growth hormone signaling pathwaydefinition[GO:0060397]  
1
  • TASUniProtKB
Negative regulation of dendritic cell cytokine productiondefinition[GO:0002731]  
  • ISSOrtholog Curator
Negative regulation of FasL biosynthetic processdefinition[GO:0045221]  
  • ISSOrtholog Curator
Negative regulation of interleukin-10 productiondefinition[GO:0032693]  
  • ISSOrtholog Curator
Negative regulation of interleukin-12 productiondefinition[GO:0032695]  
  • ISSOrtholog Curator
Negative regulation of T cell activationdefinition[GO:0050868]  
  • ISSOrtholog Curator
Negative regulation of T-helper 1 cell differentiationdefinition[GO:0045626]  
  • ISSOrtholog Curator
Negative regulation of thymocyte apoptotic processdefinition[GO:0070244]  
  • ISSOrtholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
  • ISSOrtholog Curator
Positive regulation of dendritic cell apoptotic processdefinition[GO:2000670] silver  
  • IEAOrtholog Compara
Positive regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001241] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASPINC
Regulation of T cell apoptotic processdefinition[GO:0070232]  
  • ISSOrtholog Curator
Response to interleukin-15definition[GO:0070672]  
1
  • TASBHF-UCL
Response to interleukin-2definition[GO:0070669]  
1
  • TASBHF-UCL
Response to interleukin-4definition[GO:0070670]  
2
  • IDABHF-UCL
Response to interleukin-9definition[GO:0071104]  
1
  • TASBHF-UCL
STAT protein import into nucleusdefinition[GO:0007262]  
1
  • TASUniProtKB
T cell homeostasisdefinition[GO:0043029]  
1
  • TASUniProtKB
  • ISSOrtholog Curator
Tyrosine phosphorylation of STAT proteindefinition[GO:0007260]  
1
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+3718  
HTLV-I infection  hsa05166+3718  
Jak-STAT signaling pathway  hsa04630+3718  
Measles  hsa05162+3718  
Primary immunodeficiency  hsa05340+3718  
According to Reactome, this protein belongs to the following pathways:
Interleukin receptor SHC signaling  REACT_23891  
Interleukin-2 signaling  REACT_27283  
Interleukin-7 signaling  REACT_115529  
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Janus_kinase_3
GenomeRNAi: 3718
PRO: PR:P52333
Chemistry
GuidetoPHARMACOLOGY: 2049