SLC7A2 - Cationic amino acid transporter 2 - human protein (Function)
 
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Protein
Gene
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SLC7A2 »  Cationic amino acid transporter 2  (CAT2)
 
Protein also known as:  Low affinity cationic amino acid transporter 2.
Gene name:  SLC7A2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 35 3
GENE REF ISO

Function

 show evidences
Overview 
Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing.  
2
  • UniProtKB
Isoform  Iso 2   Functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport.  
3
  • UniProtKB
Isoform  Iso 1   Functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2.  
2
  • UniProtKB
According to TCDB this is a transporter from family:
the amino acid-polyamine-organocation (apc) family  2.A.3.3.8  
GO molecular function 
Antiporter activitydefinition[GO:0015297]  
1
  • RefGenome
Arginine transmembrane transporter activitydefinition[GO:0015181]  
1
  • RefGenome
Basic amino acid transmembrane transporter activitydefinition[GO:0015174]  
1
  • PINC
High-affinity arginine transmembrane transporter activitydefinition[GO:0005289] silver  
1
  • Ortholog Compara
High-affinity L-ornithine transmembrane transporter activitydefinition[GO:0097627] silver  
1
  • Ortholog Compara
High-affinity lysine transmembrane transporter activitydefinition[GO:0005292] silver  
1
  • Ortholog Compara
L-lysine transmembrane transporter activitydefinition[GO:0015189]  
1
  • RefGenome
L-ornithine transmembrane transporter activitydefinition[GO:0000064]  
1
  • RefGenome
Low-affinity L-arginine transmembrane transporter activitydefinition[GO:0097626] silver  
1
  • Ortholog Compara
GO biological process 
Cellular amino acid metabolic processdefinition[GO:0006520]  
1
  • PINC
L-arginine import across plasma membranedefinition[GO:0097638]  
1
  • RefGenome
L-lysine import across plasma membranedefinition[GO:0097639] silver  
1
  • Ortholog Compara
L-lysine transmembrane transportdefinition[GO:1903401]  
1
  • RefGenome
L-ornithine import across plasma membranedefinition[GO:0097640] silver  
1
  • Ortholog Compara
L-ornithine transmembrane transportdefinition[GO:1903352]  
1
  • RefGenome
Macrophage activationdefinition[GO:0042116] silver  
1
  • Ortholog Compara
Nitric oxide biosynthetic processdefinition[GO:0006809] silver  
1
  • Ortholog Compara
Nitric oxide production involved in inflammatory responsedefinition[GO:0002537] silver  
1
  • Ortholog Compara
Regulation of inflammatory responsedefinition[GO:0050727] silver  
1
  • Ortholog Compara
Regulation of macrophage activationdefinition[GO:0043030] silver  
1
  • Ortholog Compara
Transportdefinition[GO:0006810]  
1
  • PINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Amino acid transport across the plasma membrane  REACT_13796  
 

Keywords

Biological process 
Amino-acid transport  definition   [KW-0029]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC7A2
GenomeRNAi: 6542
PRO: PR:P52569