CHN2 - Beta-chimaerin - human protein (Function)
 
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Protein
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References

 
CHN2 »  Beta-chimaerin
 
Protein also known as:  Rho GTPase-activating protein 3.
Gene name:  CHN2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.  
  • CuratedUniProtKB
GO molecular function 
GTPase activator activitydefinition[GO:0005096]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
SH3/SH2 adaptor activitydefinition[GO:0005070]  
1
  • TASPINC
GO biological process 
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • TASGOC
Positive regulation of signal transductiondefinition[GO:0009967]  
1
  • TASGOC
Enzymatic activity 
It is regulated in the following manner
In the inactive state, the N terminus protrudes into the active site of the Rho-GAP domain, sterically blocking Rac binding. Phospholipid binding to the Phorbol-ester/DAG-type zinc-finger/C1 domain triggers the cooperative dissociation of these interactions, allowing the N-terminus to move out of the active site and thereby activating the enzyme.  
1
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
GTPase activation  definition   [KW-0343]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Chimerin_2
GenomeRNAi: 1124
PRO: PR:P52757