HK2 - Hexokinase-2 - human protein (Function)
 
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HK2 »  Hexokinase-2   [ EC 2.7.1.1 ]
 
Protein also known as:  Muscle form hexokinase.
Gene name:  HK2
Family name: Hexokinase
Entry whose protein(s) existence is based on evidence at protein level
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1 91 1
GENE REF ISO

Function

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GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
Fructokinase activitydefinition[GO:0008865] silver  
  • IBARefGenome
Glucokinase activitydefinition[GO:0004340] silver  
  • IBARefGenome
Glucose bindingdefinition[GO:0005536] silver  
  • IEAOrtholog Compara
Hexokinase activitydefinition[GO:0004396]  
1
  • TASPINC
Mannokinase activitydefinition[GO:0019158] silver  
  • IBARefGenome
GO biological process 
Apoptotic mitochondrial changesdefinition[GO:0008637]  
1
  • IDAMGI
Carbohydrate phosphorylationdefinition[GO:0046835] silver  
  • IEAOrtholog Compara
Cellular glucose homeostasisdefinition[GO:0001678] silver  
  • IBARefGenome
Glucose 6-phosphate metabolic processdefinition[GO:0051156] silver  
  • IBARefGenome
Glucose metabolic processdefinition[GO:0006006] silver  
  • IEAOrtholog Compara
Glycolytic processdefinition[GO:0006096] silver  
  • IBARefGenome
Lactationdefinition[GO:0007595] silver  
  • IEAOrtholog Compara
Regulation of glucose importdefinition[GO:0046324] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.1.1: ATP + D-hexose ADP + D-hexose 6-phosphate.  
  • CuratedUniProtKB
It is regulated in the following manner
Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Amino sugar and nucleotide sugar metabolism  hsa00520+3099  
Butirosin and neomycin biosynthesis  hsa00524+3099  
Carbohydrate digestion and absorption  hsa04973+3099  
Fructose and mannose metabolism  hsa00051+3099  
Galactose metabolism  hsa00052+3099  
Glycolysis / Gluconeogenesis  hsa00010+3099  
Insulin signaling pathway  hsa04910+3099  
Metabolic pathways  hsa01100+3099  
Starch and sucrose metabolism  hsa00500+3099  
Type II diabetes mellitus  hsa04930+3099  
According to Reactome, this protein belongs to the following pathway:
Glucose transport  REACT_212  
 
More information is available from:
Note 
In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).  
  • CuratedUniProtKB
 

Keywords

Biological process 
Glycolysis  definition   [KW-0324]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P52789
Other
GeneWiki: HK2
GenomeRNAi: 3099
PRO: PR:P52789