EFNA3 - Ephrin-A3 - human protein (Function)
 
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Protein
Gene
References

 
EFNA3 »  Ephrin-A3
 
Protein also known as:  EPH-related receptor tyrosine kinase ligand 3 (LERK-3).
Gene name:  EFNA3
Family name: Ephrin
Entry whose protein(s) existence is based on evidence at protein level
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1 18 2
GENE REF ISO

Function

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Overview 
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Ephrin receptor bindingdefinition[GO:0046875]  
1
  • IPIUniProtKB
Transmembrane-ephrin receptor activitydefinition[GO:0005005]  
1
  • TASPINC
GO biological process 
Axon guidancedefinition[GO:0007411] silver  
  • IBARefGenome
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Ephrin receptor signaling pathwaydefinition[GO:0048013]  
  • IBARefGenome
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+1944  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: EFNA3
GenomeRNAi: 1944
PRO: PR:P52797