AKR1C2 - Aldo-keto reductase family 1 member C2 - human protein (Function)
 
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AKR1C2 »  Aldo-keto reductase family 1 member C2   [ EC 1.-.-.- ]
 
Protein also known as:  Dihydrodiol dehydrogenase/bile acid-binding protein (DD/BABP).
Gene name:  AKR1C2
Family name: Aldo/keto reductase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 57 2
GENE REF ISO

Function

 show evidences
Overview 
Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.  
5
  • UniProtKB
GO molecular function 
Alditol:NADP+ 1-oxidoreductase activitydefinition[GO:0004032]  
1
  • UniProtKB
Bile acid bindingdefinition[GO:0032052]  
1
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Carboxylic acid bindingdefinition[GO:0031406]  
1
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Ketosteroid monooxygenase activitydefinition[GO:0047086]  
1
  • UniProtKB
Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptordefinition[GO:0016655]  
1
  • UniProtKB
Phenanthrene 9,10-monooxygenase activitydefinition[GO:0018636]  
1
  • UniProtKB
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activitydefinition[GO:0047115]  
1
  • UniProtKB
GO biological process 
Cellular response to jasmonic acid stimulusdefinition[GO:0071395]  
1
  • UniProtKB
Cellular response to prostaglandin D stimulusdefinition[GO:0071799]  
1
  • UniProtKB
Daunorubicin metabolic processdefinition[GO:0044597]  
1
  • UniProtKB
Digestiondefinition[GO:0007586]  
1
  • UniProtKB
Doxorubicin metabolic processdefinition[GO:0044598]  
1
  • UniProtKB
Epithelial cell differentiationdefinition[GO:0030855]  
1
  • UniProtKB
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • UniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
1
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • UniProtKB
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • UniProtKB
Progesterone metabolic processdefinition[GO:0042448]  
1
  • UniProtKB
Prostaglandin metabolic processdefinition[GO:0006693]  
1
  • UniProtKB
Steroid metabolic processdefinition[GO:0008202]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.3.1.20: Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) catechol + NADPH.  
1
  • UniProtKB
EC 1.1.1.357: A 3-alpha-hydroxysteroid + NAD(P)(+) a 3-oxosteroid + NAD(P)H.  
1
  • UniProtKB
It is regulated in the following manner
Inhibited by hexestrol with an IC(50) of 2.8 uM, 1,10-phenanthroline with an IC(50) of 2100 uM, 1,7-phenanthroline with an IC(50) of 1500 uM, flufenamic acid with an IC(50) of 0.9 uM, indomethacin with an IC(50) of 75 uM, ibuprofen with an IC(50) of 6.9 uM, lithocholic acid with an IC(50) of 0.07 uM, ursodeoxycholic acid with an IC(50) of 0.08 uM and chenodeoxycholic acid with an IC(50) of 0.13 uM.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolism of xenobiotics by cytochrome P450  hsa00980+1646  
Steroid hormone biosynthesis  hsa00140+1646  
According to Reactome, this protein belongs to the following pathways:
Synthesis of bile acids and bile salts via 24-hydroxycholesterol  REACT_11053  
Synthesis of bile acids and bile salts via 27-hydroxycholesterol  REACT_11048  
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol  REACT_11041  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 79 uM for PGD2
KM 260 uM for (s)-tetralol
KM 520 uM for (s)-indan-1-ol
KM 1 uM for 5-beta-pregnane-3-alpha,20-alpha-diol
KM 208 uM for 9-alpha,11-beta-PGF2
KM 0.3 uM for 5-beta-androstane-3,17-dione
KM 5000 uM for benzene dihydrodiol

Keywords

Biological process 
Lipid metabolism  definition   [KW-0443]
Steroid metabolism  definition   [KW-0753]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P52895
Other
GenomeRNAi: 1646
PRO: PR:P52895