AKR1C2 - Aldo-keto reductase family 1 member C2 - human protein (Function)
 
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AKR1C2 »  Aldo-keto reductase family 1 member C2   [ EC 1.-.-.- ]
 
Protein also known as:  Dihydrodiol dehydrogenase/bile acid-binding protein (DD/BABP).
Gene name:  AKR1C2
Family name: Aldo/keto reductase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 53 2
GENE REF ISO

Function

 show evidences
Overview 
Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.  
1
  • CuratedUniProtKB
GO molecular function 
Alditol:NADP+ 1-oxidoreductase activitydefinition[GO:0004032]  
1
  • IDAUniProtKB
Bile acid bindingdefinition[GO:0032052]  
1
  • IDAUniProtKB
Carboxylic acid bindingdefinition[GO:0031406]  
1
  • IDAUniProtKB
Ketosteroid monooxygenase activitydefinition[GO:0047086]  
1
  • IDAUniProtKB
Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptordefinition[GO:0016655]  
1
  • IDAUniProtKB
Phenanthrene 9,10-monooxygenase activitydefinition[GO:0018636]  
1
  • IDAUniProtKB
Prostaglandin F receptor activitydefinition[GO:0004958]  
1
  • IDAUniProtKB
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activitydefinition[GO:0047115]  
1
  • IDAUniProtKB
GO biological process 
Cellular response to jasmonic acid stimulusdefinition[GO:0071395]  
1
  • IDAUniProtKB
Daunorubicin metabolic processdefinition[GO:0044597]  
1
  • IMPUniProtKB
Digestiondefinition[GO:0007586]  
1
  • IDAUniProtKB
Doxorubicin metabolic processdefinition[GO:0044598]  
1
  • IMPUniProtKB
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDAUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDAUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDAUniProtKB
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • IDAUniProtKB
Progesterone metabolic processdefinition[GO:0042448]  
1
  • IDAUniProtKB
Prostaglandin metabolic processdefinition[GO:0006693]  
1
  • IDAUniProtKB
Response to prostaglandindefinition[GO:0034694]  
1
  • IDAUniProtKB
Steroid metabolic processdefinition[GO:0008202]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.3.1.20: Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) catechol + NADPH.  
1
  • CuratedUniProtKB
EC 1.1.1.357: A 3-alpha-hydroxysteroid + NAD(P)(+) a 3-oxosteroid + NAD(P)H.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by hexestrol with an IC(50) of 2.8 uM, 1,10-phenanthroline with an IC(50) of 2100 uM, 1,7-phenanthroline with an IC(50) of 1500 uM, flufenamic acid with an IC(50) of 0.9 uM, indomethacin with an IC(50) of 75 uM, ibuprofen with an IC(50) of 6.9 uM, lithocholic acid with an IC(50) of 0.07 uM, ursodeoxycholic acid with an IC(50) of 0.08 uM and chenodeoxycholic acid with an IC(50) of 0.13 uM.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolism of xenobiotics by cytochrome P450  hsa00980+1646  
Steroid hormone biosynthesis  hsa00140+1646  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 79 uM for PGD2
KM 260 uM for (s)-tetralol
KM 520 uM for (s)-indan-1-ol
KM 1 uM for 5-beta-pregnane-3-alpha,20-alpha-diol
KM 208 uM for 9-alpha,11-beta-PGF2
KM 0.3 uM for 5-beta-androstane-3,17-dione
KM 5000 uM for benzene dihydrodiol

Keywords

Biological process 
Lipid metabolism  definition   [KW-0443]
Steroid metabolism  definition   [KW-0753]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P52895
Other
GenomeRNAi: 1646
PRO: PR:P52895