PDX1 - Pancreas/duodenum homeobox protein 1 - human protein (Function)
 
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PDX1 »  Pancreas/duodenum homeobox protein 1  (PDX-1)
 
Protein also known as:  Somatostatin-transactivating factor 1 (STF-1).
Gene name:  PDX1
Family name: Antp homeobox » IPF1/XlHbox-8
Entry whose protein(s) existence is based on evidence at protein level
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1 104 1
GENE REF ISO

Function

 show evidences
Overview 
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.  
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Core promoter sequence-specific DNA bindingdefinition[GO:0001046] silver  
  • IEAOrtholog Compara
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • TASBHF-UCL
Transcription factor bindingdefinition[GO:0008134] silver  
  • IEAOrtholog Compara
GO biological process 
Central nervous system developmentdefinition[GO:0007417] silver  
  • IEAOrtholog Compara
Detection of glucosedefinition[GO:0051594]  
  • ISSOrtholog Curator
Digestive tract developmentdefinition[GO:0048565] silver  
  • IEAOrtholog Compara
Exocrine pancreas developmentdefinition[GO:0031017] silver  
  • IEAOrtholog Compara
Generation of precursor metabolites and energydefinition[GO:0006091]  
1
  • TASPINC
Glucose homeostasisdefinition[GO:0042593] silver  
  • IEAOrtholog Compara
Glucose metabolic processdefinition[GO:0006006] silver  
  • IEAOrtholog Compara
Insulin secretiondefinition[GO:0030073]  
1
  • IDABHF-UCL
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Morphogenesis of embryonic epitheliumdefinition[GO:0016331] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Nitric oxide mediated signal transductiondefinition[GO:0007263]  
1
  • IDABHF-UCL
Organ morphogenesisdefinition[GO:0009887]  
1
  • TASPINC
Organ regenerationdefinition[GO:0031100] silver  
  • IEAOrtholog Compara
Organ senescencedefinition[GO:0010260] silver  
  • IEAOrtholog Compara
Positive regulation of cell deathdefinition[GO:0010942] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of DNA bindingdefinition[GO:0043388] silver  
  • IEAOrtholog Compara
Positive regulation of insulin secretiondefinition[GO:0032024] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
  • ISSOrtholog Curator
Response to chloratedefinition[GO:0010157] silver  
  • IEAOrtholog Compara
Response to cytokinedefinition[GO:0034097] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to fatty aciddefinition[GO:0070542] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to iron(II) iondefinition[GO:0010040] silver  
  • IEAOrtholog Compara
Response to leucinedefinition[GO:0043201] silver  
  • IEAOrtholog Compara
Response to nicotinedefinition[GO:0035094] silver  
  • IEAOrtholog Compara
Response to vitamindefinition[GO:0033273] silver  
  • IEAOrtholog Compara
Response to woundingdefinition[GO:0009611] silver  
  • IEAOrtholog Compara
Smoothened signaling pathwaydefinition[GO:0007224] silver  
  • IEAOrtholog Compara
Stem cell differentiationdefinition[GO:0048863] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
  • IEAOrtholog Compara
Transdifferentiationdefinition[GO:0060290] silver  
  • IEAOrtholog Compara
Type B pancreatic cell differentiationdefinition[GO:0003309]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Maturity onset diabetes of the young  hsa04950+3651  
Type II diabetes mellitus  hsa04930+3651  
According to Reactome, this protein belongs to the following pathway:
Developmental Biology  REACT_111045  
Note 
According to PubMed16141209, it may be methylated by SETD7 in vitro. However, the relevance of methylation is unsure in vivo.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PDX1
GenomeRNAi: 3651
PRO: PR:P52945