PPP5C - Serine/threonine-protein phosphatase 5 - human protein (Function)
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PPP5C »  Serine/threonine-protein phosphatase 5   [ EC ]  (PP5)
Protein also known as:  Protein phosphatase T (PPT).
Gene name:  PPP5C
Family name: PPP phosphatase » PP-5 (PP-T)
Entry whose protein(s) existence is based on evidence at protein level
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Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.  
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
  • IPIIntAct
Lipid bindingdefinition[GO:0008289]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Phosphoprotein phosphatase activitydefinition[GO:0004721]  
  • ISSUniProtKB
Protein bindingdefinition[GO:0005515]  
  • IPIIntAct
  • IPIUniProtKB
Protein serine/threonine phosphatase activitydefinition[GO:0004722]  
RNA bindingdefinition[GO:0003723] silver  
  • IEAOrtholog Compara
Signal transducer activitydefinition[GO:0004871]  
  • IMPUniProtKB
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
DNA repairdefinition[GO:0006281]  
  • IEAUniProtKB KW
Mitotic nuclear divisiondefinition[GO:0007067]  
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
  • IMPUniProtKB
Protein dephosphorylationdefinition[GO:0006470] silver  
  • IEAInterPro 2 GO
Protein heterooligomerizationdefinition[GO:0051291] silver  
  • IEAOrtholog Compara
Response to morphinedefinition[GO:0043278] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
Transcription, DNA-templateddefinition[GO:0006351]  
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC [a protein]-serine/threonine phosphate + H(2)O [a protein]-serine/threonine + phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 magnesium or manganese per subunit.  
  • CuratedUniProtKB
It is regulated in the following manner
Autoinhibited. In the autoinhibited state, the TPR domain interacts with the catalytic region and prevents substrate access to the catalytic pocket. Allosterically activated by various polyunsaturated fatty acids, free long-chain fatty-acids and long-chain fatty acyl-CoA esters, arachidonic acid being the most effective activator. HSP90A and probably RAC1, GNA12 and GNA13 can also release the autoinhibition by the TPR repeat. Activation by RAC1, GNA12 and GNA13 is synergistic with the one produced by fatty acids binding. Inhibited by okadaic acid.  
  • CuratedUniProtKB
According to KEGG, this protein belongs to the following pathway:
MAPK signaling pathway  hsa04010+5536  

Biophysicochemical properties

Kinetic parameters
KM 1.847 uM for CSNK1E (at 30 degrees Celsius)
KM 13.2 uM for MAPT/TAU (at pH 7.4 and 30 degrees Celsius)


Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: PPP5C
GenomeRNAi: 5536
PRO: PR:P53041