PPP5C - Serine/threonine-protein phosphatase 5 - human protein (Function)
 
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PPP5C »  Serine/threonine-protein phosphatase 5   [ EC 3.1.3.16 ]  (PP5)
 
Protein also known as:  Protein phosphatase T (PPT).
Gene name:  PPP5C
Family name: PPP phosphatase » PP-5 (PP-T)
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.  
16
  • UniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
1
  • IntAct
Lipid bindingdefinition[GO:0008289]  
1
  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Phosphoprotein phosphatase activitydefinition[GO:0004721]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IntAct
  • UniProtKB
Protein serine/threonine phosphatase activitydefinition[GO:0004722]  
1
  • PINC
RNA bindingdefinition[GO:0003723] silver  
1
  • Ortholog Compara
Signal transducer activitydefinition[GO:0004871]  
1
  • UniProtKB
GO biological process 
DNA repairdefinition[GO:0006281]  
1
  • UniProtKB KW
Mitotic nuclear divisiondefinition[GO:0007067]  
1
  • PINC
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • UniProtKB
Protein dephosphorylationdefinition[GO:0006470] silver  
1
  • InterPro 2 GO
Protein heterooligomerizationdefinition[GO:0051291] silver  
1
  • Ortholog Compara
Response to morphinedefinition[GO:0043278] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • GOC
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • PINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.16: [a protein]-serine/threonine phosphate + H(2)O [a protein]-serine/threonine + phosphate.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+) : Binds 2 Mg(2+) or Mn(2+) cations per subunit.  
1
  • UniProtKB
It is regulated in the following manner
Autoinhibited. In the autoinhibited state, the TPR domain interacts with the catalytic region and prevents substrate access to the catalytic pocket. Allosterically activated by various polyunsaturated fatty acids, free long-chain fatty-acids and long-chain fatty acyl-CoA esters, arachidonic acid being the most effective activator. HSP90A and probably RAC1, GNA12 and GNA13 can also release the autoinhibition by the TPR repeat. Activation by RAC1, GNA12 and GNA13 is synergistic with the one produced by fatty acids binding. Inhibited by okadaic acid.  
7
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
MAPK signaling pathway  hsa04010+5536  
 

Biophysicochemical properties

Kinetic parameters
KM 1.847 uM for CSNK1E (at 30 degrees Celsius)
KM 13.2 uM for MAPT/TAU (at pH 7.4 and 30 degrees Celsius)

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PPP5C
GenomeRNAi: 5536
PRO: PR:P53041