NUBP1 - Cytosolic Fe-S cluster assembly factor NUBP1 - human protein (Function)
 
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NUBP1 »  Cytosolic Fe-S cluster assembly factor NUBP1
 
Protein also known as:  Nucleotide-binding protein 1 (NBP 1).
Gene name:  NUBP1
Entry whose protein(s) existence is based on evidence at protein level
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1 20 2
GENE REF ISO

Function

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Overview 
Implicated in the regulation of centrosome duplication (By similarity). Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.  
1
  • CuratedUniProtKB
GO molecular function 
4 iron, 4 sulfur cluster bindingdefinition[GO:0051539]  
  • IEAUniProtKB Annot
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Iron-sulfur cluster bindingdefinition[GO:0051536]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Nucleoside-triphosphatase activitydefinition[GO:0017111] silver  
  • IEAInterPro 2 GO
Nucleotide bindingdefinition[GO:0000166]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Cell growthdefinition[GO:0016049]  
1
  • IMPUniProtKB
Cellular iron ion homeostasisdefinition[GO:0006879]  
1
  • IMPUniProtKB
Centrosome localizationdefinition[GO:0051642] silver  
  • IEAOrtholog Compara
Iron-sulfur cluster assemblydefinition[GO:0016226]  
1
  • IMPUniProtKB
Negative regulation of centrosome duplicationdefinition[GO:0010826] silver  
  • IEAOrtholog Compara
Protein localization to cell cortexdefinition[GO:0072697] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It requires the following cofactor
Binds 4 4Fe-4S clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer (By similarity).  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 4682
PRO: PR:P53384