ACLY - ATP-citrate synthase - human protein (Function)
 
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ACLY »  ATP-citrate synthase   [ EC 2.3.3.8 ]
 
Protein also known as:  ATP-citrate (pro-S-)-lyase (ACL).
Gene name:  ACLY
Family names: In the N-terminal section Succinate/malate CoA ligase beta subunit
In the C-terminal section Succinate/malate CoA ligase alpha subunit
Entry whose protein(s) existence is based on evidence at protein level
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1 65 2
GENE REF ISO

Function

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Overview 
ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATP citrate synthase activitydefinition[GO:0003878]  
1
  • TASUniProtKB
Cofactor bindingdefinition[GO:0048037] silver  
  • IEAInterPro 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Succinate-CoA ligase (ADP-forming) activitydefinition[GO:0004775] silver  
  • IEAInterPro 2 GO
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • TASPINC
Cellular carbohydrate metabolic processdefinition[GO:0044262] silver  
  • IEAInterPro 2 GO
Citrate metabolic processdefinition[GO:0006101]  
1
  • TASPINC
Coenzyme A metabolic processdefinition[GO:0015936]  
1
  • TASPINC
Lipid biosynthetic processdefinition[GO:0008610]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.3.8: ADP + phosphate + acetyl-CoA + oxaloacetate ATP + citrate + CoA.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Citrate cycle (TCA cycle)  hsa00020+47  
Metabolic pathways  hsa01100+47  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P53396
Other
GenomeRNAi: 47
PRO: PR:P53396