SUCLG1 - Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial - human protein (Function)
 
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SUCLG1 »  Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial   [ EC 6.2.1.4EC 6.2.1.5 ]
 
Protein also known as:  Succinyl-CoA synthetase subunit alpha (SCS-alpha).
Gene name:  SUCLG1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP citrate synthase activitydefinition[GO:0003878] silver  
  • IEAInterPro 2 GO
Cofactor bindingdefinition[GO:0048037] silver  
  • IEAInterPro 2 GO
GDP bindingdefinition[GO:0019003] silver  
  • IEAOrtholog Compara
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Succinate-CoA ligase (ADP-forming) activitydefinition[GO:0004775]  
  • IEAEC 2 GO
Succinate-CoA ligase (GDP-forming) activitydefinition[GO:0004776]  
  • IEAEC 2 GO
GO biological process 
Succinate metabolic processdefinition[GO:0006105] silver  
  • IEAOrtholog Compara
Succinyl-CoA metabolic processdefinition[GO:0006104] silver  
  • IEAOrtholog Compara
Tricarboxylic acid cycledefinition[GO:0006099]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 6.2.1.4: GTP + succinate + CoA GDP + phosphate + succinyl-CoA.  
  • CuratedUniProtKB
EC 6.2.1.5: ATP + succinate + CoA ADP + phosphate + succinyl-CoA.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Citrate cycle (TCA cycle)  hsa00020+8802  
Metabolic pathways  hsa01100+8802  
Propanoate metabolism  hsa00640+8802  
According to Reactome, this protein belongs to the following pathway:
Citric acid cycle (TCA cycle)  REACT_1785  
 
More information is available from:
 

Keywords

Biological process 
Tricarboxylic acid cycle  definition   [KW-0816]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SUCLG1
GenomeRNAi: 8802
PRO: PR:P53597