CTSC - Dipeptidyl peptidase 1 - human protein (Function)
 
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CTSC »  Dipeptidyl peptidase 1   [ EC 3.4.14.1 ]
 
Protein also known as:  Dipeptidyl peptidase I (DPPI). Cleaved into:  Dipeptidyl peptidase 1 exclusion domain chain; Dipeptidyl peptidase 1 heavy chain; Dipeptidyl peptidase 1 light chain.
Gene name:  CTSC
Family name: Peptidase C1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 79 3
GENE REF ISO

Function

 show evidences
Overview 
Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.  
2
  • UniProtKB
GO molecular function 
Chaperone bindingdefinition[GO:0051087]  
1
  • BHF-UCL
Chloride ion bindingdefinition[GO:0031404] silver  
1
  • Ortholog Compara
Cysteine-type peptidase activitydefinition[GO:0008234]  
1
  • UniProtKB
Identical protein bindingdefinition[GO:0042802] silver  
1
  • Ortholog Compara
Peptidase activator activity involved in apoptotic processdefinition[GO:0016505] silver  
1
  • Ortholog Compara
Phosphatase bindingdefinition[GO:0019902]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein self-associationdefinition[GO:0043621] silver  
1
  • Ortholog Compara
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
1
  • Ortholog Compara
GO biological process 
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Apoptotic processdefinition[GO:0006915] silver  
1
  • Ortholog Compara
Immune responsedefinition[GO:0006955]  
1
  • PINC
Positive regulation of apoptotic signaling pathwaydefinition[GO:2001235] silver  
1
  • Ortholog Compara
Positive regulation of proteolysis involved in cellular protein catabolic processdefinition[GO:1903052]  
1
  • ParkinsonsUK-UCL
Proteolysisdefinition[GO:0006508]  
1
  • UniProtKB
Response to organic substancedefinition[GO:0010033] silver  
1
  • Ortholog Compara
T cell mediated cytotoxicitydefinition[GO:0001913] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.14.1: Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.  
1
  • UniProtKB
It requires the following cofactor
 chloride : Binds 1 Cl(-) ion per heavy chain.  
1
  • UniProtKB
It is regulated in the following manner
Strongly inhibited by the cysteine peptidase inhibitors mersalyl acid, iodoacetic acid and cystatin. Inhibited by N-ethylmaleimide, Gly-Phe-diazomethane, TLCK, TPCK and, at low pH, by dithiodipyridine. Not inhibited by the serine peptidase inhibitor PMSF, the aminopeptidase inhibitor bestatin, or metal ion chelators.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Lysosome  hsa04142+1075  
According to Reactome, this protein belongs to the following pathway:
MHC class II antigen presentation  REACT_121399  
 
More information is available from:
 

Biophysicochemical properties

Dependence
pH High activity at pH 4.5-6.8.

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P53634
Other
GeneWiki: Cathepsin_C
GenomeRNAi: 1075
PRO: PR:P53634