CTSC - Dipeptidyl peptidase 1 - human protein (Function)
 
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CTSC »  Dipeptidyl peptidase 1   [ EC 3.4.14.1 ]
 
Protein also known as:  Dipeptidyl peptidase I (DPPI). Cleaved into:  Dipeptidyl peptidase 1 exclusion domain chain; Dipeptidyl peptidase 1 heavy chain; Dipeptidyl peptidase 1 light chain.
Gene name:  CTSC
Family name: Peptidase C1
Entry whose protein(s) existence is based on evidence at protein level
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1 76 3
GENE REF ISO

Function

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Overview 
Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.  
1
  • CuratedUniProtKB
GO molecular function 
Chaperone bindingdefinition[GO:0051087]  
1
  • ISSBHF-UCL
Chloride ion bindingdefinition[GO:0031404] silver  
  • IEAOrtholog Compara
Cysteine-type peptidase activitydefinition[GO:0008234]  
1
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802] silver  
  • IEAOrtholog Compara
Peptidase activator activity involved in apoptotic processdefinition[GO:0016505] silver  
  • IEAOrtholog Compara
Phosphatase bindingdefinition[GO:0019902]  
1
  • ISSBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein self-associationdefinition[GO:0043621] silver  
  • IEAOrtholog Compara
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
  • IEAOrtholog Compara
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915] silver  
  • IEAOrtholog Compara
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Positive regulation of apoptotic signaling pathwaydefinition[GO:2001235] silver  
  • IEAOrtholog Compara
Positive regulation of proteolysis involved in cellular protein catabolic processdefinition[GO:1903052]  
1
  • ISSParkinsonsUK-UCL
Proteolysisdefinition[GO:0006508]  
1
  • IDAUniProtKB
Response to organic substancedefinition[GO:0010033] silver  
  • IEAOrtholog Compara
T cell mediated cytotoxicitydefinition[GO:0001913] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.14.1: Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 chloride ion per heavy chain.  
  • CuratedUniProtKB
It is regulated in the following manner
Strongly inhibited by the cysteine peptidase inhibitors mersalyl acid, iodoacetic acid and cystatin. Inhibited by N-ethylmaleimide, Gly-Phe-diazomethane, TLCK, TPCK and, at low pH, by dithiodipyridine. Not inhibited by the serine peptidase inhibitor PMSF, the aminopeptidase inhibitor bestatin, or metal ion chelators.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Lysosome  hsa04142+1075  
According to Reactome, this protein belongs to the following pathway:
MHC class II antigen presentation  REACT_121399  
 
More information is available from:
 

Biophysicochemical properties

Dependence
pH High activity at pH 4.5-6.8.

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P53634
Other
GeneWiki: Cathepsin_C
GenomeRNAi: 1075
PRO: PR:P53634