LIMK1 - LIM domain kinase 1 - human protein (Function)
 
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LIMK1 »  LIM domain kinase 1   [ EC 2.7.11.1 ]  (LIMK-1)
 
Gene name:  LIMK1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development.  
8
  • CuratedUniProtKB
Isoform  Iso 3   Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).  
8
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Heat shock protein bindingdefinition[GO:0031072]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein kinase activitydefinition[GO:0004672]  
1
  • NASPINC
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036]  
1
  • TASPINC
Negative regulation of ubiquitin-protein transferase activitydefinition[GO:0051444]  
1
  • IDABHF-UCL
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Positive regulation of actin filament bundle assemblydefinition[GO:0032233]  
1
  • IDABHF-UCL
Positive regulation of axon extensiondefinition[GO:0045773]  
  • ISSOrtholog Curator
Protein phosphorylationdefinition[GO:0006468]  
2
  • IMPUniProtKB
  • IDABHF-UCL
Rho protein signal transductiondefinition[GO:0007266]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
2
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+3984  
Fc gamma R-mediated phagocytosis  hsa04666+3984  
Regulation of actin cytoskeleton  hsa04810+3984  
According to Reactome, this protein belongs to the following pathways:
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
Sema3A PAK dependent Axon repulsion  REACT_19236  
Sema4D induced cell migration and growth-cone collapse  REACT_19277  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: LIMK1
GenomeRNAi: 3984
PRO: PR:P53667
Chemistry
GuidetoPHARMACOLOGY: 2054