LIMK2 - LIM domain kinase 2 - human protein (Function)
 
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LIMK2 »  LIM domain kinase 2   [ EC 2.7.11.1 ]  (LIMK-2)
 
Gene name:  LIMK2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 48 3
GENE REF ISO

Function

 show evidences
Overview 
Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • TASUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Phosphorylationdefinition[GO:0016310]  
1
  • TASUniProtKB
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+3985  
Fc gamma R-mediated phagocytosis  hsa04666+3985  
Regulation of actin cytoskeleton  hsa04810+3985  
According to Reactome, this protein belongs to the following pathway:
Developmental Biology  REACT_111045  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: LIMK2
GenomeRNAi: 3985
PRO: PR:P53671
Chemistry
GuidetoPHARMACOLOGY: 2055