ITGA8 - Integrin alpha-8 - human protein (Function)
 
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ITGA8 »  Integrin alpha-8
 
Cleaved into:  Integrin alpha-8 heavy chain; Integrin alpha-8 light chain.
Gene name:  ITGA8
Family name: Integrin alpha chain
Entry whose protein(s) existence is based on evidence at protein level
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1 44 1
GENE REF ISO

Function

 show evidences
Overview 
Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.  
2
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Cell projection organizationdefinition[GO:0030030] silver  
  • IEAOrtholog Compara
Cell-matrix adhesiondefinition[GO:0007160]  
1
  • NASUniProtKB
Establishment of protein localizationdefinition[GO:0045184] silver  
  • IEAOrtholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
  • IEAOrtholog Compara
Integrin-mediated signaling pathwaydefinition[GO:0007229]  
  • IEAUniProtKB KW
Memorydefinition[GO:0007613] silver  
  • IEAOrtholog Compara
Metanephros developmentdefinition[GO:0001656] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiationdefinition[GO:2000721] silver  
  • IEAOrtholog Compara
Positive regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0030511] silver  
  • IEAOrtholog Compara
Single organismal cell-cell adhesiondefinition[GO:0016337]  
1
  • NASUniProtKB
Smooth muscle tissue developmentdefinition[GO:0048745] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+8516  
Cell adhesion molecules (CAMs)  hsa04514+8516  
Dilated cardiomyopathy  hsa05414+8516  
ECM-receptor interaction  hsa04512+8516  
Focal adhesion  hsa04510+8516  
Hypertrophic cardiomyopathy (HCM)  hsa05410+8516  
Regulation of actin cytoskeleton  hsa04810+8516  
According to Reactome, this protein belongs to the following pathways:
ECM proteoglycans  REACT_163906  
Integrin cell surface interactions  REACT_13552  
Molecules associated with elastic fibres  REACT_150331  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Integrin  definition   [KW-0401]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ITGA8
GenomeRNAi: 8516
PRO: PR:P53708