MAPK10 - Mitogen-activated protein kinase 10 - human protein (Function)
 
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MAPK10 »  Mitogen-activated protein kinase 10   [ EC 2.7.11.24 ]  (MAPK 10)
 
Protein also known as:  Stress-activated protein kinase JNK3.
Gene name:  MAPK10
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
JUN kinase activitydefinition[GO:0004705]  
1
  • ISSUniProtKB
MAP kinase kinase activitydefinition[GO:0004708]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • TASGOC
JNK cascadedefinition[GO:0007254]  
1
  • ISSUniProtKB
JUN phosphorylationdefinition[GO:0007258]  
2
  • TASGOC
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.24: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Activated by threonine and tyrosine phosphorylation by two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K7 phosphorylates MAPK10 on Thr-221 causing a conformational change and a large increase in Vmax. MAP2K4 then phosphorylates Tyr-223 resulting in a further increase in Vmax. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by HDAC9.  
2
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+5602  
Chagas disease (American trypanosomiasis)  hsa05142+5602  
Colorectal cancer  hsa05210+5602  
Dopaminergic synapse  hsa04728+5602  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+5602  
ErbB signaling pathway  hsa04012+5602  
Fc epsilon RI signaling pathway  hsa04664+5602  
Focal adhesion  hsa04510+5602  
GnRH signaling pathway  hsa04912+5602  
Hepatitis C  hsa05160+5602  
Herpes simplex infection  hsa05168+5602  
HTLV-I infection  hsa05166+5602  
Influenza A  hsa05164+5602  
Insulin signaling pathway  hsa04910+5602  
MAPK signaling pathway  hsa04010+5602  
Neurotrophin signaling pathway  hsa04722+5602  
NOD-like receptor signaling pathway  hsa04621+5602  
Osteoclast differentiation  hsa04380+5602  
Pancreatic cancer  hsa05212+5602  
Pathways in cancer  hsa05200+5602  
Pertussis  hsa05133+5602  
Progesterone-mediated oocyte maturation  hsa04914+5602  
Protein processing in endoplasmic reticulum  hsa04141+5602  
RIG-I-like receptor signaling pathway  hsa04622+5602  
Salmonella infection  hsa05132+5602  
Shigellosis  hsa05131+5602  
Toll-like receptor signaling pathway  hsa04620+5602  
Toxoplasmosis  hsa05145+5602  
Tuberculosis  hsa05152+5602  
Type II diabetes mellitus  hsa04930+5602  
Wnt signaling pathway  hsa04310+5602  
According to Reactome, this protein belongs to the following pathways:
Cellular responses to stress  REACT_120956  
Immune System  REACT_6900  
TRAF6 Mediated Induction of proinflammatory cytokines  REACT_6782  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAPK10
GenomeRNAi: 5602
PRO: PR:P53779
Chemistry
GuidetoPHARMACOLOGY: 1498