POLR2K - DNA-directed RNA polymerases I, II, and III subunit RPABC4 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
POLR2K »  DNA-directed RNA polymerases I, II, and III subunit RPABC4  (RNA polymerases I, II, and III subunit ABC4)
 
Protein also known as:  DNA-directed RNA polymerase II subunit K.
Gene name:  POLR2K
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 9 1
GENE REF ISO

Function

 show evidences
Overview 
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
Contributes to RNA polymerase I activitydefinition[GO:0001054] silver  
  • IBARefGenome
Contributes to RNA polymerase II activitydefinition[GO:0001055] silver  
  • IBARefGenome
Contributes to RNA polymerase III activitydefinition[GO:0001056] silver  
  • IBARefGenome
Zinc ion bindingdefinition[GO:0008270]  
1
  • TASPINC
GO biological process 
Regulation of transcription from RNA polymerase I promoterdefinition[GO:0006356]  
1
  • TASPINC
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytosolic DNA-sensing pathway  hsa04623+5440  
Huntington's disease  hsa05016+5440  
Metabolic pathways  hsa01100+5440  
Purine metabolism  hsa00230+5440  
Pyrimidine metabolism  hsa00240+5440  
RNA polymerase  hsa03020+5440  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
DNA Repair  REACT_216  
Elongation arrest and recovery  REACT_1892  
Gene Expression  REACT_71  
Immune System  REACT_6900  
mRNA Processing  REACT_1675  
Transcription  REACT_1788  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: POLR2K
GenomeRNAi: 5440
PRO: PR:P53803