POLR2K - DNA-directed RNA polymerases I, II, and III subunit RPABC4 - human protein (Function)
 
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POLR2K »  DNA-directed RNA polymerases I, II, and III subunit RPABC4  (RNA polymerases I, II, and III subunit ABC4)
 
Protein also known as:  DNA-directed RNA polymerase II subunit K.
Gene name:  POLR2K
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 9 1
GENE REF ISO

Function

 show evidences
Overview 
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
Contributes to RNA polymerase I activitydefinition[GO:0001054] silver  
  • IBARefGenome
Contributes to RNA polymerase II activitydefinition[GO:0001055] silver  
  • IBARefGenome
Contributes to RNA polymerase III activitydefinition[GO:0001056] silver  
  • IBARefGenome
Zinc ion bindingdefinition[GO:0008270]  
1
  • TASPINC
GO biological process 
Regulation of transcription from RNA polymerase I promoterdefinition[GO:0006356]  
1
  • TASPINC
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytosolic DNA-sensing pathway  hsa04623+5440  
Huntington's disease  hsa05016+5440  
Metabolic pathways  hsa01100+5440  
Purine metabolism  hsa00230+5440  
Pyrimidine metabolism  hsa00240+5440  
RNA polymerase  hsa03020+5440  
According to Reactome, this protein belongs to the following pathways:
Abortive elongation of HIV-1 transcript in the absence of Tat  REACT_6261  
Dual incision reaction in TC-NER  REACT_2222  
Formation of HIV elongation complex in the absence of HIV Tat  REACT_22201  
Formation of HIV-1 elongation complex containing HIV-1 Tat  REACT_6346  
Formation of the Early Elongation Complex  REACT_846  
Formation of the HIV-1 Early Elongation Complex  REACT_6319  
Formation of transcription-coupled NER (TC-NER) repair complex  REACT_1941  
HIV elongation arrest and recovery  REACT_6259  
HIV Transcription Initiation  REACT_6332  
MicroRNA (miRNA) biogenesis  REACT_12417  
mRNA Capping  REACT_1470  
mRNA Splicing - Major Pathway  REACT_467  
mRNA Splicing - Minor Pathway  REACT_1753  
NoRC negatively regulates rRNA expression  REACT_200856  
Pausing and recovery of HIV elongation  REACT_6244  
Pausing and recovery of Tat-mediated HIV elongation  REACT_6143  
Processing of Capped Intron-Containing Pre-mRNA  REACT_125  
RNA Pol II CTD phosphorylation and interaction with CE  REACT_975  
RNA Pol II CTD phosphorylation and interaction with CE  REACT_6237  
RNA Polymerase I Chain Elongation  REACT_2204  
RNA Polymerase I Promoter Escape  REACT_1913  
RNA Polymerase I Transcription Initiation  REACT_953  
RNA Polymerase I Transcription Termination  REACT_1074  
RNA Polymerase II HIV Promoter Escape  REACT_6253  
RNA Polymerase II Pre-transcription Events  REACT_22107  
RNA Polymerase II Promoter Escape  REACT_2089  
RNA Polymerase II Transcription Elongation  REACT_833  
RNA Polymerase II Transcription Initiation  REACT_1851  
RNA Polymerase II Transcription Initiation And Promoter Clearance  REACT_834  
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening  REACT_1655  
RNA Polymerase III Abortive And Retractive Initiation  REACT_22339  
RNA Polymerase III Chain Elongation  REACT_756  
RNA Polymerase III Transcription Initiation From Type 1 Promoter  REACT_347  
RNA Polymerase III Transcription Initiation From Type 2 Promoter  REACT_1036  
RNA Polymerase III Transcription Initiation From Type 3 Promoter  REACT_571  
RNA Polymerase III Transcription Termination  REACT_63  
Tat-mediated elongation of the HIV-1 transcript  REACT_6162  
Tat-mediated HIV elongation arrest and recovery  REACT_6344  
Transcription of the HIV genome  REACT_6233  
Transcription-coupled NER (TC-NER)  REACT_1628  
Viral Messenger RNA Synthesis  REACT_6354  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: POLR2K
GenomeRNAi: 5440
PRO: PR:P53803