POLR2K - DNA-directed RNA polymerases I, II, and III subunit RPABC4 - human protein (Function)
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POLR2K »  DNA-directed RNA polymerases I, II, and III subunit RPABC4  (RNA polymerases I, II, and III subunit ABC4)
Protein also known as:  DNA-directed RNA polymerase II subunit K.
Gene name:  POLR2K
Entry whose protein(s) existence is based on evidence at protein level
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DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.  
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • InterPro 2 GO
Contributes to RNA polymerase I activitydefinition[GO:0001054]  
  • RefGenome
Contributes to RNA polymerase II activitydefinition[GO:0001055]  
  • RefGenome
Contributes to RNA polymerase III activitydefinition[GO:0001056]  
  • RefGenome
Zinc ion bindingdefinition[GO:0008270]  
  • PINC
GO biological process 
Regulation of transcription from RNA polymerase I promoterdefinition[GO:0006356]  
  • PINC
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Cytosolic DNA-sensing pathway  hsa04623+5440  
Huntington's disease  hsa05016+5440  
Metabolic pathways  hsa01100+5440  
Purine metabolism  hsa00230+5440  
Pyrimidine metabolism  hsa00240+5440  
RNA polymerase  hsa03020+5440  
According to Reactome, this protein belongs to the following pathways:
Abortive elongation of HIV-1 transcript in the absence of Tat  R-HSA-167242  
Cytosolic sensors of pathogen-associated DNA  R-HSA-1834949  
Dual incision in TC-NER  R-HSA-6782135  
Formation of HIV elongation complex in the absence of HIV Tat  R-HSA-167152  
Formation of HIV-1 elongation complex containing HIV-1 Tat  R-HSA-167200  
Formation of RNA Pol II elongation complex  R-HSA-112382  
Formation of TC-NER Pre-Incision Complex  R-HSA-6781823  
Formation of the Early Elongation Complex  R-HSA-113418  
Formation of the HIV-1 Early Elongation Complex  R-HSA-167158  
Gap-filling DNA repair synthesis and ligation in TC-NER  R-HSA-6782210  
HIV elongation arrest and recovery  R-HSA-167287  
HIV Transcription Initiation  R-HSA-167161  
MicroRNA (miRNA) biogenesis  R-HSA-203927  
mRNA Capping  R-HSA-72086  
mRNA Splicing - Major Pathway  R-HSA-72163  
mRNA Splicing - Minor Pathway  R-HSA-72165  
NoRC negatively regulates rRNA expression  R-HSA-427413  
Pausing and recovery of HIV elongation  R-HSA-167290  
Pausing and recovery of Tat-mediated HIV elongation  R-HSA-167238  
PIWI-interacting RNA (piRNA) biogenesis  R-HSA-5601884  
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation  R-HSA-2892247  
Processing of Capped Intron-Containing Pre-mRNA  R-HSA-72203  
RNA Pol II CTD phosphorylation and interaction with CE  R-HSA-167160  
RNA Pol II CTD phosphorylation and interaction with CE  R-HSA-77075  
RNA Polymerase I Chain Elongation  R-HSA-73777  
RNA Polymerase I Promoter Escape  R-HSA-73772  
RNA Polymerase I Transcription Initiation  R-HSA-73762  
RNA Polymerase I Transcription Termination  R-HSA-73863  
RNA Polymerase II HIV Promoter Escape  R-HSA-167162  
RNA Polymerase II Pre-transcription Events  R-HSA-674695  
RNA Polymerase II Promoter Escape  R-HSA-73776  
RNA Polymerase II Transcription Elongation  R-HSA-75955  
RNA Polymerase II Transcription Initiation  R-HSA-75953  
RNA Polymerase II Transcription Initiation And Promoter Clearance  R-HSA-76042  
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening  R-HSA-73779  
RNA Polymerase III Abortive And Retractive Initiation  R-HSA-749476  
RNA Polymerase III Chain Elongation  R-HSA-73780  
RNA Polymerase III Transcription Initiation From Type 1 Promoter  R-HSA-76061  
RNA Polymerase III Transcription Initiation From Type 2 Promoter  R-HSA-76066  
RNA Polymerase III Transcription Initiation From Type 3 Promoter  R-HSA-76071  
RNA Polymerase III Transcription Termination  R-HSA-73980  
Tat-mediated elongation of the HIV-1 transcript  R-HSA-167246  
Tat-mediated HIV elongation arrest and recovery  R-HSA-167243  
Transcription of the HIV genome  R-HSA-167172  
Transcription-Coupled Nucleotide Excision Repair (TC-NER)  R-HSA-6781827  
Transcriptional regulation by small RNAs  R-HSA-5578749  
Transcriptional regulation of pluripotent stem cells  R-HSA-452723  
Viral Messenger RNA Synthesis  R-HSA-168325  


Biological process 
Transcription  definition   [KW-0804]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: POLR2K
GenomeRNAi: 5440
PRO: PR:P53803