SLC16A1 - Monocarboxylate transporter 1 - human protein (Function)
 
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Protein
Gene
References

 
SLC16A1 »  Monocarboxylate transporter 1
 
Gene name:  SLC16A1
Entry whose protein(s) existence is based on evidence at protein level
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1 87 1
GENE REF ISO

Function

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Overview 
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.13.1  
GO molecular function 
Mevalonate transmembrane transporter activitydefinition[GO:0015130]  
1
  • TASPINC
Monocarboxylic acid transmembrane transporter activitydefinition[GO:0008028]  
1
  • TASPINC
Organic cyclic compound bindingdefinition[GO:0097159] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Secondary active monocarboxylate transmembrane transporter activitydefinition[GO:0015355] silver  
  • IEAInterPro 2 GO
Symporter activitydefinition[GO:0015293]  
  • IEAUniProtKB KW
GO biological process 
Cellular response to organic cyclic compounddefinition[GO:0071407] silver  
  • IEAOrtholog Compara
Centrosome organizationdefinition[GO:0051297]  
1
  • IMPUniProtKB
Mevalonate transportdefinition[GO:0015728]  
1
  • TASPINC
Monocarboxylic acid transportdefinition[GO:0015718]  
1
  • TASPINC
Plasma membrane lactate transportdefinition[GO:0035879]  
  • ISSOrtholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathways:
Basigin interactions  REACT_12560  
Proton-coupled monocarboxylate transport  REACT_20515  
Pyruvate metabolism  REACT_2071  
 
More information is available from:
Note 
Overexpression in pancreatic beta-cells triggers insulin secretion in response to pyruvate, causing hyperinsulemia and hypoglycemia during strenuous exercise.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P53985
Other
GenomeRNAi: 6566
PRO: PR:P53985