SLC16A1 - Monocarboxylate transporter 1 - human protein (Function)
 
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Protein
Gene
References

 
SLC16A1 »  Monocarboxylate transporter 1  (MCT 1)
 
Protein also known as:  Solute carrier family 16 member 1.
Gene name:  SLC16A1
Entry whose protein(s) existence is based on evidence at protein level
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1 79 1
GENE REF ISO

Function

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Overview 
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.13.1  
GO molecular function 
Mevalonate transmembrane transporter activitydefinition[GO:0015130]  
1
  • TASPINC
Monocarboxylic acid transmembrane transporter activitydefinition[GO:0008028]  
1
  • TASPINC
Organic cyclic compound bindingdefinition[GO:0097159] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Secondary active monocarboxylate transmembrane transporter activitydefinition[GO:0015355] silver  
  • IEAInterPro 2 GO
Symporter activitydefinition[GO:0015293]  
  • IEAUniProtKB KW
GO biological process 
Cellular response to organic cyclic compounddefinition[GO:0071407] silver  
  • IEAOrtholog Compara
Centrosome organizationdefinition[GO:0051297]  
1
  • IMPUniProtKB
Mevalonate transportdefinition[GO:0015728]  
1
  • TASPINC
Monocarboxylic acid transportdefinition[GO:0015718]  
1
  • TASPINC
Plasma membrane lactate transportdefinition[GO:0035879]  
  • ISSOrtholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathways:
Bile salt and organic anion SLC transporters  REACT_20633  
Hemostasis  REACT_604  
Metabolism  REACT_111217  
Transmembrane transport of small molecules  REACT_15518  
 
More information is available from:
 

Keywords

Biological process 
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P53985
Other
GenomeRNAi: 6566
PRO: PR:P53985