CLNS1A - Methylosome subunit pICln - human protein (Function)
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CLNS1A »  Methylosome subunit pICln
Protein also known as:  Chloride conductance regulatory protein ICln (I(Cln)).
Gene name:  CLNS1A
Family name: pICln (TC 1.A.47)
Entry whose protein(s) existence is based on evidence at protein level
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1 47 1


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Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the nucleotide-sensitive anion-selective channel, icln (icln) family  1.A.47.1.1  
GO molecular function 
Poly(A) RNA bindingdefinition[GO:0044822]  
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Cell volume homeostasisdefinition[GO:0006884] silver  
  • IEAInterPro 2 GO
Chloride transportdefinition[GO:0006821] silver  
  • IEAInterPro 2 GO
Spliceosomal snRNP assemblydefinition[GO:0000387]  
  • IDAUniProtKB
According to KEGG, this protein belongs to the following pathway:
RNA transport  hsa03013+1207  
According to Reactome, this protein belongs to the following pathway:
snRNP Assembly  REACT_11066  


Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: CLNS1A
GenomeRNAi: 1207
PRO: PR:P54105