BLM - Bloom syndrome protein - human protein (Function)
 
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BLM »  Bloom syndrome protein   [ EC 3.6.4.12 ]
 
Protein also known as:  DNA helicase, RecQ-like type 2 (RecQ2).
Gene name:  BLM
Family name: Helicase » RecQ
Entry whose protein(s) existence is based on evidence at protein level
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1 171 1
GENE REF ISO

Function

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Overview 
Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).  
4
  • CuratedUniProtKB
GO molecular function 
Annealing helicase activitydefinition[GO:0036310]  
1
  • IDAUniProtKB
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
ATP-dependent 3'-5' DNA helicase activitydefinition[GO:0043140] silver  
  • IEAOrtholog Compara
ATP-dependent DNA helicase activitydefinition[GO:0004003]  
2
  • IMPUniProtKB
ATP-dependent helicase activitydefinition[GO:0008026]  
1
  • IDAUniProtKB
ATPase activitydefinition[GO:0016887]  
1
  • IDAUniProtKB
Bubble DNA bindingdefinition[GO:0000405]  
1
  • IDAUniProtKB
Four-way junction helicase activitydefinition[GO:0009378]  
2
  • IDAUniProtKB
G-quadruplex DNA bindingdefinition[GO:0051880]  
1
  • IDAUniProtKB
Helicase activitydefinition[GO:0004386]  
3
  • IDAUniProtKB
P53 bindingdefinition[GO:0002039]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
18
  • IPIUniProtKB
  • IPIIntAct
  • IPIBHF-UCL
Single-stranded DNA bindingdefinition[GO:0003697]  
1
  • IDAUniProtKB
GO biological process 
Alpha-beta T cell differentiationdefinition[GO:0046632] silver  
  • IEAOrtholog Compara
ATP catabolic processdefinition[GO:0006200]  
2
  • IDAGOC
Cellular response to camptothecindefinition[GO:0072757]  
1
  • IDAUniProtKB
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
2
  • IDAUniProtKB
Cellular response to hydroxyureadefinition[GO:0072711]  
1
  • IDAUniProtKB
Cellular response to ionizing radiationdefinition[GO:0071479]  
1
  • IDAUniProtKB
DNA double-strand break processingdefinition[GO:0000729]  
1
  • IDAUniProtKB
DNA duplex unwindingdefinition[GO:0032508]  
4
  • IMPGOC
DNA recombinationdefinition[GO:0006310]  
2
  • NASUniProtKB
DNA repairdefinition[GO:0006281]  
1
  • NASUniProtKB
DNA strand renaturationdefinition[GO:0000733]  
1
  • IDAGOC
Double-strand break repair via homologous recombinationdefinition[GO:0000724]  
1
  • NASUniProtKB
G2 DNA damage checkpointdefinition[GO:0031572]  
1
  • NASUniProtKB
Mitotic G2 phasedefinition[GO:0000085]  
1
  • NASUniProtKB
Negative regulation of cell divisiondefinition[GO:0051782]  
1
  • IMPUniProtKB
Negative regulation of DNA recombinationdefinition[GO:0045910]  
1
  • IMPUniProtKB
Negative regulation of mitotic recombinationdefinition[GO:0045950] silver  
  • IEAOrtholog Compara
Negative regulation of thymocyte apoptotic processdefinition[GO:0070244] silver  
  • IEAOrtholog Compara
Positive regulation of alpha-beta T cell proliferationdefinition[GO:0046641] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Protein oligomerizationdefinition[GO:0051259]  
1
  • IDAUniProtKB
Regulation of bindingdefinition[GO:0051098] silver  
  • IEAOrtholog Compara
Regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0000079]  
1
  • IMPUniProtKB
Replication fork processingdefinition[GO:0031297]  
1
  • IDAUniProtKB
Replication fork protectiondefinition[GO:0048478]  
1
  • NASUniProtKB
Response to X-raydefinition[GO:0010165]  
1
  • IDAUniProtKB
Telomere maintenancedefinition[GO:0000723] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.12: ATP + H(2)O ADP + phosphate.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Fanconi anemia pathway  hsa03460+641  
Homologous recombination  hsa03440+641  
According to Reactome, this protein belongs to the following pathway:
Cell Cycle  REACT_115566  
 

Keywords

Biological process 
DNA replication  definition   [KW-0235]
Molecular function 
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Bloom_syndrome_protein
GenomeRNAi: 641
PRO: PR:P54132