SLC18A1 - Chromaffin granule amine transporter - human protein (Function)
 
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Protein
Gene
References

 
SLC18A1 »  Chromaffin granule amine transporter
 
Protein also known as:  Solute carrier family 18 member 1.
Gene name:  SLC18A1
Entry whose protein(s) existence is based on evidence at transcript level
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1 20 3
GENE REF ISO

Function

 show evidences
Overview 
Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.2.12  
GO molecular function 
Drug transmembrane transporter activitydefinition[GO:0015238] silver  
  • IEAInterPro 2 GO
Monoamine transmembrane transporter activitydefinition[GO:0008504]  
1
  • TASUniProtKB
GO biological process 
Monoamine transportdefinition[GO:0015844]  
1
  • TASUniProtKB
Neurotransmitter transportdefinition[GO:0006836]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Dopaminergic synapse  hsa04728+6570  
Parkinson's disease  hsa05012+6570  
Synaptic vesicle cycle  hsa04721+6570  
According to Reactome, this protein belongs to the following pathways:
Amine compound SLC transporters  REACT_20679  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Neurotransmitter transport  definition   [KW-0532]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 6570
PRO: PR:P54219
Chemistry
GuidetoPHARMACOLOGY: 1011