ATN1 - Atrophin-1 - human protein (Function)
 
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Protein
Gene
References

 
ATN1 »  Atrophin-1
 
Protein also known as:  Dentatorubral-pallidoluysian atrophy protein.
Gene name:  ATN1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Asn (polyQ) repeats.  
3
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
5
  • UniProtKB
  • IntAct
Protein domain specific bindingdefinition[GO:0019904]  
1
  • UniProtKB
Transcription corepressor activitydefinition[GO:0003714]  
1
  • UniProtKB
GO biological process 
Central nervous system developmentdefinition[GO:0007417]  
1
  • PINC
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • UniProtKB
Neuron apoptotic processdefinition[GO:0051402]  
1
  • UniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATN1
GenomeRNAi: 1822
PRO: PR:P54259