CACNB3 - Voltage-dependent L-type calcium channel subunit beta-3 - human protein (Function)
 
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CACNB3 »  Voltage-dependent L-type calcium channel subunit beta-3  (CAB3)
 
Protein also known as:  Calcium channel voltage-dependent subunit beta 3.
Gene name:  CACNB3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 19 5
GENE REF ISO

Function

 show evidences
Overview 
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ca(2+) channel auxiliary subunit types 1-4 (cca-) family  8.A.22.1.3  
GO molecular function 
Protein kinase bindingdefinition[GO:0019901] silver  
  • IEAOrtholog Compara
Contributes to voltage-gated calcium channel activitydefinition[GO:0005245]  
1
  • IDAUniProtKB
GO biological process 
Calcium ion transportdefinition[GO:0006816]  
1
  • IDAUniProtKB
T cell receptor signaling pathwaydefinition[GO:0050852] silver  
  • IEAOrtholog Compara
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+784  
Cardiac muscle contraction  hsa04260+784  
Dilated cardiomyopathy  hsa05414+784  
Hypertrophic cardiomyopathy (HCM)  hsa05410+784  
MAPK signaling pathway  hsa04010+784  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Metabolism  REACT_111217  
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CACNB3
GenomeRNAi: 784
PRO: PR:P54284