CACNA2D1 - Voltage-dependent calcium channel subunit alpha-2/delta-1 - human protein (Function)
 
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CACNA2D1 »  Voltage-dependent calcium channel subunit alpha-2/delta-1
 
Protein also known as:  Voltage-gated calcium channel subunit alpha-2/delta-1. Cleaved into:  Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1.
Gene name:  CACNA2D1
Entry whose protein(s) existence is based on evidence at protein level
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1 46 5
GENE REF ISO

Function

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Overview 
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ca(2+) channel auxiliary subunit 2 types 1-4 (cca-2) family  8.A.18.1.1  
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Contributes to voltage-gated calcium channel activitydefinition[GO:0005245]  
2
  • IDAUniProtKB
  • IDABHF-UCL
GO biological process 
Calcium ion transmembrane transportdefinition[GO:0070588]  
  • IEAUniProtKB KW
Calcium ion transportdefinition[GO:0006816]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Regulation of calcium ion transportdefinition[GO:0051924]  
1
  • IDABHF-UCL
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+781  
Cardiac muscle contraction  hsa04260+781  
Dilated cardiomyopathy  hsa05414+781  
Hypertrophic cardiomyopathy (HCM)  hsa05410+781  
MAPK signaling pathway  hsa04010+781  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CACNA2D1
GenomeRNAi: 781
PRO: PR:P54289