ATP12A - Potassium-transporting ATPase alpha chain 2 - human protein (Function)
 
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ATP12A »  Potassium-transporting ATPase alpha chain 2   [ EC 3.6.3.10 ]
 
Protein also known as:  Non-gastric H(+)/K(+) ATPase subunit alpha.
Gene name:  ATP12A
Entry whose protein(s) existence is based on evidence at protein level
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1 43 2
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.  
1
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Hydrogen:potassium-exchanging ATPase activitydefinition[GO:0008900]  
1
  • EC 2 GO
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Sodium:potassium-exchanging ATPase activitydefinition[GO:0005391] silver  
1
  • InterPro 2 GO
GO biological process 
Hydrogen ion transmembrane transportdefinition[GO:1902600]  
1
  • EC 2 GO
Metabolic processdefinition[GO:0008152]  
1
  • UniProtKB KW
Potassium ion homeostasisdefinition[GO:0055075] silver  
1
  • Ortholog Compara
Potassium ion transportdefinition[GO:0006813]  
1
  • UniProtKB KW
Regulation of pHdefinition[GO:0006885] silver  
1
  • Ortholog Compara
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • InterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.10: ATP + H(2)O + H(+)(In) + K(+)(Out) ADP + phosphate + H(+)(Out) + K(+)(In).  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Oxidative phosphorylation  hsa00190+479  
According to Reactome, this protein belongs to the following pathway:
Ion transport by P-type ATPases  REACT_25149  
 

Keywords

Biological process 
Hydrogen ion transport  definition   [KW-0375]
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP12A
GenomeRNAi: 479
PRO: PR:P54707