ATP12A - Potassium-transporting ATPase alpha chain 2 - human protein (Function)
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ATP12A »  Potassium-transporting ATPase alpha chain 2   [ EC ]
Protein also known as:  Non-gastric H(+)/K(+) ATPase subunit alpha.
Gene name:  ATP12A
Entry whose protein(s) existence is based on evidence at protein level
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Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Hydrogen:potassium-exchanging ATPase activitydefinition[GO:0008900]  
  • IEAEC 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
ATP biosynthetic processdefinition[GO:0006754] silver  
  • IEAInterPro 2 GO
Hydrogen ion transmembrane transportdefinition[GO:1902600]  
  • IEAEC 2 GO
Potassium ion homeostasisdefinition[GO:0055075] silver  
  • IEAOrtholog Compara
Potassium ion transportdefinition[GO:0006813]  
  • IEAUniProtKB KW
Regulation of pHdefinition[GO:0006885] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC ATP + H(2)O + H(+)(In) + K(+)(Out) ADP + phosphate + H(+)(Out) + K(+)(In).  
  • CuratedUniProtKB
More information is available from:
According to KEGG, this protein belongs to the following pathway:
Oxidative phosphorylation  hsa00190+479  
According to Reactome, this protein belongs to the following pathway:
Ion transport by P-type ATPases  REACT_25149  


Biological process 
Hydrogen ion transport  definition   [KW-0375]
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: ATP12A
GenomeRNAi: 479
PRO: PR:P54707