ATP1B3 - Sodium/potassium-transporting ATPase subunit beta-3 - human protein (Function)
 
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ATP1B3 »  Sodium/potassium-transporting ATPase subunit beta-3
 
Protein also known as:  Sodium/potassium-dependent ATPase subunit beta-3 (ATPB-3); CD antigen CD298.
Gene name:  ATP1B3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 23 2
GENE REF ISO

Function

 show evidences
Overview 
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the p-type atpase (p-atpase) superfamily  3.A.3.1.1  
GO molecular function 
ATPase activator activitydefinition[GO:0001671]  
1
  • BHF-UCL
ATPase bindingdefinition[GO:0051117]  
1
  • BHF-UCL
Contributes to sodium:potassium-exchanging ATPase activitydefinition[GO:0005391]  
2
  • BHF-UCL
GO biological process 
Cellular potassium ion homeostasisdefinition[GO:0030007]  
2
  • BHF-UCL
Cellular sodium ion homeostasisdefinition[GO:0006883]  
2
  • BHF-UCL
Membrane repolarizationdefinition[GO:0086009]  
1
  • BHF-UCL
Positive regulation of ATP catabolic processdefinition[GO:1903291]  
1
  • BHF-UCL
Positive regulation of ATPase activitydefinition[GO:0032781]  
1
  • BHF-UCL
Positive regulation of potassium ion importdefinition[GO:1903288]  
1
  • BHF-UCL
Positive regulation of potassium ion transmembrane transporter activitydefinition[GO:1901018]  
1
  • BHF-UCL
Positive regulation of sodium ion export from celldefinition[GO:1903278]  
1
  • BHF-UCL
Potassium ion importdefinition[GO:0010107]  
2
  • BHF-UCL
Protein localization to plasma membranedefinition[GO:0072659]  
1
  • BHF-UCL
Protein stabilizationdefinition[GO:0050821]  
1
  • BHF-UCL
Sodium ion export from celldefinition[GO:0036376]  
2
  • BHF-UCL
Transportdefinition[GO:0006810]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+483  
Bile secretion  hsa04976+483  
Carbohydrate digestion and absorption  hsa04973+483  
Cardiac muscle contraction  hsa04260+483  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+483  
Gastric acid secretion  hsa04971+483  
Mineral absorption  hsa04978+483  
Pancreatic secretion  hsa04972+483  
Protein digestion and absorption  hsa04974+483  
Proximal tubule bicarbonate reclamation  hsa04964+483  
Salivary secretion  hsa04970+483  
According to Reactome, this protein belongs to the following pathways:
Basigin interactions  REACT_12560  
Ion transport by P-type ATPases  REACT_25149  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Sodium transport  definition   [KW-0739]
Sodium/potassium transport  definition   [KW-0740]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP1B3
GenomeRNAi: 483
PRO: PR:P54709