EPHB3 - Ephrin type-B receptor 3 - human protein (Function)
 
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EPHB3 »  Ephrin type-B receptor 3   [ EC 2.7.10.1 ]
 
Protein also known as:  Tyrosine-protein kinase TYRO6.
Gene name:  EPHB3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 68 1
GENE REF ISO

Function

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Overview 
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Axon guidance receptor activitydefinition[GO:0008046] silver  
1
  • Ortholog Compara
Ephrin receptor activitydefinition[GO:0005003]  
2
  • UniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • Ortholog Curator
Axon guidancedefinition[GO:0007411]  
1
  • Ortholog Curator
Axonal fasciculationdefinition[GO:0007413]  
1
  • Ortholog Curator
Cell migrationdefinition[GO:0016477]  
1
  • UniProtKB
Central nervous system projection neuron axonogenesisdefinition[GO:0021952] silver  
1
  • Ortholog Compara
Corpus callosum developmentdefinition[GO:0022038]  
1
  • Ortholog Curator
Dendritic spine developmentdefinition[GO:0060996]  
1
  • Ortholog Curator
Dendritic spine morphogenesisdefinition[GO:0060997]  
1
  • Ortholog Curator
Digestive tract morphogenesisdefinition[GO:0048546]  
1
  • Ortholog Curator
Ephrin receptor signaling pathwaydefinition[GO:0048013]  
2
  • UniProtKB
Palate developmentdefinition[GO:0060021]  
1
  • Ortholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
3
  • InterPro 2 GO
  • EC 2 GO
  • UniProtKB KW
Positive regulation of synapse assemblydefinition[GO:0051965]  
1
  • Ortholog Curator
Protein autophosphorylationdefinition[GO:0046777]  
2
  • UniProtKB
Regulation of axonogenesisdefinition[GO:0050770]  
1
  • Ortholog Curator
Regulation of Cdc42 GTPase activitydefinition[GO:0043088]  
1
  • UniProtKB
Regulation of cell-cell adhesiondefinition[GO:0022407]  
1
  • UniProtKB
Regulation of Rac GTPase activitydefinition[GO:0032314]  
1
  • UniProtKB
Retinal ganglion cell axon guidancedefinition[GO:0031290] silver  
1
  • Ortholog Compara
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446]  
1
  • UniProtKB
Thymus developmentdefinition[GO:0048538]  
1
  • Ortholog Curator
Urogenital system developmentdefinition[GO:0001655]  
1
  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • UniProtKB
  • PROSITE-ProRule
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+2049  
According to Reactome, this protein belongs to the following pathways:
EPH-ephrin mediated repulsion of cells  REACT_228189  
EPH-Ephrin signaling  REACT_228170  
EPHB-mediated forward signaling  REACT_228085  
Ephrin signaling  REACT_228226  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EPHB3
GenomeRNAi: 2049
PRO: PR:P54753
Chemistry
GuidetoPHARMACOLOGY: 1832