EPHB3 - Ephrin type-B receptor 3 - human protein (Function)
 
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EPHB3 »  Ephrin type-B receptor 3   [ EC 2.7.10.1 ]
 
Protein also known as:  Tyrosine-protein kinase TYRO6.
Gene name:  EPHB3
Entry whose protein(s) existence is based on evidence at protein level
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1 64 1
GENE REF ISO

Function

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Overview 
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. Beside its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Axon guidance receptor activitydefinition[GO:0008046] silver  
  • IEAOrtholog Compara
Ephrin receptor activitydefinition[GO:0005003]  
2
  • IDAUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
  • ISSOrtholog Curator
Axon guidancedefinition[GO:0007411]  
  • ISSOrtholog Curator
Axonal fasciculationdefinition[GO:0007413]  
  • ISSOrtholog Curator
Cell migrationdefinition[GO:0016477]  
1
  • IDAUniProtKB
Central nervous system projection neuron axonogenesisdefinition[GO:0021952] silver  
  • IEAOrtholog Compara
Corpus callosum developmentdefinition[GO:0022038]  
  • ISSOrtholog Curator
Dendritic spine developmentdefinition[GO:0060996]  
  • ISSOrtholog Curator
Dendritic spine morphogenesisdefinition[GO:0060997]  
  • ISSOrtholog Curator
Digestive tract morphogenesisdefinition[GO:0048546]  
  • ISSOrtholog Curator
Ephrin receptor signaling pathwaydefinition[GO:0048013]  
2
  • IDAUniProtKB
Palate developmentdefinition[GO:0060021]  
  • ISSOrtholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
  • IEAUniProtKB KW
  • IEAInterPro 2 GO
  • IEAEC 2 GO
Positive regulation of synapse assemblydefinition[GO:0051965]  
  • ISSOrtholog Curator
Protein autophosphorylationdefinition[GO:0046777]  
2
  • IDAUniProtKB
Regulation of axonogenesisdefinition[GO:0050770]  
  • ISSOrtholog Curator
Regulation of Cdc42 GTPase activitydefinition[GO:0043088]  
1
  • IDAUniProtKB
Regulation of cell-cell adhesiondefinition[GO:0022407]  
1
  • IDAUniProtKB
Regulation of Rac GTPase activitydefinition[GO:0032314]  
1
  • IDAUniProtKB
Retinal ganglion cell axon guidancedefinition[GO:0031290] silver  
  • IEAOrtholog Compara
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446]  
1
  • IDAUniProtKB
Thymus developmentdefinition[GO:0048538]  
  • ISSOrtholog Curator
Urogenital system developmentdefinition[GO:0001655]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+2049  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EPHB3
GenomeRNAi: 2049
PRO: PR:P54753
Chemistry
GuidetoPHARMACOLOGY: 1832