EPHB4 - Ephrin type-B receptor 4 - human protein (Function)
 
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EPHB4 »  Ephrin type-B receptor 4   [ EC 2.7.10.1 ]
 
Protein also known as:  Tyrosine-protein kinase TYRO11.
Gene name:  EPHB4
Entry whose protein(s) existence is based on evidence at protein level
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1 101 1
GENE REF ISO

Function

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Overview 
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Ephrin receptor activitydefinition[GO:0005003]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Transmembrane receptor protein tyrosine kinase activitydefinition[GO:0004714]  
1
  • IDAUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
  • ISSOrtholog Curator
Cell adhesiondefinition[GO:0007155]  
1
  • IDAUniProtKB
Cell migration involved in sprouting angiogenesisdefinition[GO:0002042]  
1
  • IDAUniProtKB
Ephrin receptor signaling pathwaydefinition[GO:0048013]  
1
  • IDAUniProtKB
Heart morphogenesisdefinition[GO:0003007]  
  • ISSOrtholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • IDAGOC
  • IEAInterPro 2 GO
  • IEAEC 2 GO
  • IEAUniProtKB KW
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+2050  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EPH_receptor_B4
GenomeRNAi: 2050
PRO: PR:P54760
Chemistry
GuidetoPHARMACOLOGY: 1833