EPHB1 - Ephrin type-B receptor 1 - human protein (Function)
 
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EPHB1 »  Ephrin type-B receptor 1   [ EC 2.7.10.1 ]
 
Protein also known as:  Neuronally-expressed EPH-related tyrosine kinase (NET).
Gene name:  EPHB1
Entry whose protein(s) existence is based on evidence at protein level
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1 55 1
GENE REF ISO

Function

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Overview 
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. Beside its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.  
5
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Axon guidance receptor activitydefinition[GO:0008046] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
5
  • IPIUniProtKB
  • IPIIntAct
Transmembrane-ephrin receptor activitydefinition[GO:0005005]  
1
  • IDAUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • IDAUniProtKB
Axon guidancedefinition[GO:0007411]  
  • ISSOrtholog Curator
Camera-type eye morphogenesisdefinition[GO:0048593] silver  
  • IEAOrtholog Compara
Cell chemotaxisdefinition[GO:0060326]  
1
  • IDAUniProtKB
Cell-substrate adhesiondefinition[GO:0031589]  
1
  • IDAUniProtKB
Central nervous system projection neuron axonogenesisdefinition[GO:0021952]  
  • ISSOrtholog Curator
Dendritic spine developmentdefinition[GO:0060996]  
  • ISSOrtholog Curator
Dendritic spine morphogenesisdefinition[GO:0060997]  
  • ISSOrtholog Curator
Detection of temperature stimulus involved in sensory perception of paindefinition[GO:0050965]  
  • ISSOrtholog Curator
Ephrin receptor signaling pathwaydefinition[GO:0048013]  
2
  • IDAUniProtKB
Establishment of cell polaritydefinition[GO:0030010]  
  • ISSOrtholog Curator
Neural precursor cell proliferationdefinition[GO:0061351]  
  • ISSOrtholog Curator
Neurogenesisdefinition[GO:0022008]  
  • ISSOrtholog Curator
Optic nerve morphogenesisdefinition[GO:0021631] silver  
  • IEAOrtholog Compara
Positive regulation of synapse assemblydefinition[GO:0051965]  
  • ISSOrtholog Curator
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Regulation of ERK1 and ERK2 cascadedefinition[GO:0070372]  
2
  • IDAUniProtKB
Regulation of JNK cascadedefinition[GO:0046328]  
1
  • IDAUniProtKB
Retinal ganglion cell axon guidancedefinition[GO:0031290]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+2047  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Neurogenesis  definition   [KW-0524]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EPH_receptor_B1
GenomeRNAi: 2047
PRO: PR:P54762
Chemistry
GuidetoPHARMACOLOGY: 1830