EPHB1 - Ephrin type-B receptor 1 - human protein (Function)
 
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Protein
Gene
References

 
EPHB1 »  Ephrin type-B receptor 1   [ EC 2.7.10.1 ]
 
Protein also known as:  Neuronally-expressed EPH-related tyrosine kinase (NET).
Gene name:  EPHB1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 65 3
GENE REF ISO

Function

 show evidences
Overview 
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.  
6
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Axon guidance receptor activitydefinition[GO:0008046] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
5
  • UniProtKB
  • IntAct
Transmembrane-ephrin receptor activitydefinition[GO:0005005]  
1
  • UniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • UniProtKB
Axon guidancedefinition[GO:0007411]  
1
  • Ortholog Curator
Camera-type eye morphogenesisdefinition[GO:0048593] silver  
1
  • Ortholog Compara
Cell chemotaxisdefinition[GO:0060326]  
1
  • UniProtKB
Cell-substrate adhesiondefinition[GO:0031589]  
1
  • UniProtKB
Central nervous system projection neuron axonogenesisdefinition[GO:0021952]  
1
  • Ortholog Curator
Dendritic spine developmentdefinition[GO:0060996]  
1
  • Ortholog Curator
Dendritic spine morphogenesisdefinition[GO:0060997]  
1
  • Ortholog Curator
Detection of temperature stimulus involved in sensory perception of paindefinition[GO:0050965]  
1
  • Ortholog Curator
Ephrin receptor signaling pathwaydefinition[GO:0048013]  
2
  • UniProtKB
Establishment of cell polaritydefinition[GO:0030010]  
1
  • Ortholog Curator
Neural precursor cell proliferationdefinition[GO:0061351]  
1
  • Ortholog Curator
Neurogenesisdefinition[GO:0022008]  
1
  • Ortholog Curator
Optic nerve morphogenesisdefinition[GO:0021631] silver  
1
  • Ortholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
3
  • EC 2 GO
  • InterPro 2 GO
  • UniProtKB KW
Positive regulation of synapse assemblydefinition[GO:0051965]  
1
  • Ortholog Curator
Protein autophosphorylationdefinition[GO:0046777]  
1
  • UniProtKB
Regulation of ERK1 and ERK2 cascadedefinition[GO:0070372]  
2
  • UniProtKB
Regulation of JNK cascadedefinition[GO:0046328]  
1
  • UniProtKB
Regulation of neuron deathdefinition[GO:1901214]  
1
  • UniProtKB
Retinal ganglion cell axon guidancedefinition[GO:0031290]  
1
  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • UniProtKB
  • PROSITE-ProRule
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+2047  
According to Reactome, this protein belongs to the following pathways:
EPH-ephrin mediated repulsion of cells  REACT_264198  
EPH-Ephrin signaling  REACT_264068  
EPHB-mediated forward signaling  REACT_263952  
Ephrin signaling  REACT_264047  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Neurogenesis  definition   [KW-0524]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EPH_receptor_B1
GenomeRNAi: 2047
PRO: PR:P54762
Chemistry
GuidetoPHARMACOLOGY: 1830