GALC - Galactocerebrosidase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
GALC »  Galactocerebrosidase
 
Gene name:  GALC
Family name: Glycosyl hydrolase 59
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 35 4
GENE REF ISO

Function

 show evidences
Overview 
Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.  
2
  • CuratedUniProtKB
GO molecular function 
Galactosylceramidase activitydefinition[GO:0004336]  
  • ISSOrtholog Curator
GO biological process 
Carbohydrate metabolic processdefinition[GO:0005975] silver  
  • IEAInterPro 2 GO
Galactosylceramide catabolic processdefinition[GO:0006683]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.2.1.46: D-galactosyl-N-acylsphingosine + H(2)O D-galactose + N-acylsphingosine.  
2
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycoside Hydrolase Family 59  GH59  
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysosome  hsa04142+2581  
Metabolic pathways  hsa01100+2581  
Sphingolipid metabolism  hsa00600+2581  
According to Reactome, this protein belongs to the following pathway:
Glycosphingolipid metabolism  REACT_116105  
 

Biophysicochemical properties

Dependence
pH Optimum pH is 4.0-4.4.
Temperature Activity is lost after heating at 52 degrees Celsius for five minutes.

Keywords

Biological process 
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Sphingolipid metabolism  definition   [KW-0746]
Molecular function 
Glycosidase  definition   [KW-0326]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Galactosylceramidase
GenomeRNAi: 2581
PRO: PR:P54803