AK2 - Adenylate kinase 2, mitochondrial - human protein (Function)
 
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AK2 »  Adenylate kinase 2, mitochondrial   [ EC 2.7.4.3 ]  (AK 2)
 
Protein also known as:  Adenylate monophosphate kinase. Cleaved into:  Adenylate kinase 2, mitochondrial, N-terminally processed.
Gene name:  AK2
Family name: Adenylate kinase » AK2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.  
1
  • CuratedUniProtKB
GO molecular function 
Adenylate kinase activitydefinition[GO:0004017]  
  • IEAEC 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
GO biological process 
ADP biosynthetic processdefinition[GO:0006172]  
  • IEAUniProtKB Annot
AMP metabolic processdefinition[GO:0046033]  
  • IEAUniProtKB Annot
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
dATP metabolic processdefinition[GO:0046060] silver  
  • IEAOrtholog Compara
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Nucleotide phosphorylationdefinition[GO:0046939]  
1
  • TASGOC
  • IEAEC 2 GO
  • IEAUniProtKB Annot
  • IEAInterPro 2 GO
  • IEAOrtholog Compara
Oxidative phosphorylationdefinition[GO:0006119] silver  
  • IEAOrtholog Compara
Response to thyroid hormonedefinition[GO:0097066] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.4.3: ATP + AMP 2 ADP.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+204  
Purine metabolism  hsa00230+204  
According to Reactome, this protein belongs to the following pathway:
Synthesis and interconversion of nucleotide di- and triphosphates  REACT_21330  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AK2
GenomeRNAi: 204
PRO: PR:P54819