AK2 - Adenylate kinase 2, mitochondrial - human protein (Function)
 
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AK2 »  Adenylate kinase 2, mitochondrial  (AK 2)
 
Protein also known as:  ATP-AMP transphosphorylase 2.
Gene name:  AK2
Family name: Adenylate kinase » AK2
One or more isoforms of this protein have been shown to exist at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Plays a key role in hematopoiesis.  
1
  • CuratedUniProtKB
GO molecular function 
Adenylate kinase activitydefinition[GO:0004017]  
  • IEAEC 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
GO biological process 
ADP biosynthetic processdefinition[GO:0006172] silver  
  • IEAOrtholog Compara
AMP metabolic processdefinition[GO:0046033] silver  
  • IEAOrtholog Compara
ATP metabolic processdefinition[GO:0046034] silver  
  • IEAOrtholog Compara
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
dATP metabolic processdefinition[GO:0046060] silver  
  • IEAOrtholog Compara
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Oxidative phosphorylationdefinition[GO:0006119] silver  
  • IEAOrtholog Compara
Response to thyroid hormone stimulusdefinition[GO:0097066] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.4.3: ATP + AMP 2 ADP.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+204  
Purine metabolism  hsa00230+204  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]