GYS2 - Glycogen [starch] synthase, liver - human protein (Function)
 
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Protein
Gene
References

 
GYS2 »  Glycogen [starch] synthase, liver   [ EC 2.4.1.11 ]
 
Gene name:  GYS2
Family name: Glycosyltransferase 3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.  
  • CuratedUniProtKB
GO molecular function 
Glycogen (starch) synthase activitydefinition[GO:0004373]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Protein homodimerization activitydefinition[GO:0042803]  
1
  • TASUniProtKB
GO biological process 
Generation of precursor metabolites and energydefinition[GO:0006091]  
1
  • TASPINC
Glycogen biosynthetic processdefinition[GO:0005978]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
  • IEAUniPathway
Response to glucosedefinition[GO:0009749]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.11: UDP-glucose ((1->4)-alpha-D-glucosyl)(n) UDP + ((1->4)-alpha-D-glucosyl)(n+1).  
  • CuratedUniProtKB
It is regulated in the following manner
Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does (By similarity).  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 3  GT3  
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Insulin signaling pathway  hsa04910+2998  
Starch and sucrose metabolism  hsa00500+2998  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 

Keywords

Biological process 
Glycogen biosynthesis  definition   [KW-0320]
Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 2998
PRO: PR:P54840