ALDH18A1 - Delta-1-pyrroline-5-carboxylate synthase - human protein (Function)
 
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ALDH18A1 »  Delta-1-pyrroline-5-carboxylate synthase  (P5CS)
 
Protein also known as:  Aldehyde dehydrogenase family 18 member A1.
Gene name:  ALDH18A1
Family names: In the N-terminal section Glutamate 5-kinase
In the C-terminal section Gamma-glutamyl phosphate reductase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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Glutamate 5-kinase activitydefinition[GO:0004349]  
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  • UniProtKB
Glutamate-5-semialdehyde dehydrogenase activitydefinition[GO:0004350]  
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Poly(A) RNA bindingdefinition[GO:0044822]  
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GO biological process 
Citrulline biosynthetic processdefinition[GO:0019240]  
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Glutamate metabolic processdefinition[GO:0006536]  
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  • UniProtKB
L-proline biosynthetic processdefinition[GO:0055129]  
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  • UniPathway
Ornithine biosynthetic processdefinition[GO:0006592]  
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  • UniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
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  • UniProtKB KW
Phosphorylationdefinition[GO:0016310]  
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  • UniProtKB KW
Proline biosynthetic processdefinition[GO:0006561]  
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Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.2.11: ATP + L-glutamate ADP + L-glutamate 5-phosphate.  
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EC 1.2.1.41: L-glutamate 5-semialdehyde + phosphate + NADP(+) L-glutamyl 5-phosphate + NADPH.  
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It is regulated in the following manners
Isoform  Long   Is insensitive to ornithine inhibition. This is due to the two amino acid insert which abolishes feedback inhibition of P5CS activity by L-ornithine.  
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Isoform  Short   Is inhibited by L-ornithine with a Ki of approximately 0.25 mm.  
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Pathways 
This protein is involved in the following pathways
Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2  
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  • UniProtKB
Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2  
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  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Arginine and proline metabolism  hsa00330+5832  
Metabolic pathways  hsa01100+5832  
According to Reactome, this protein belongs to the following pathway:
Amino acid synthesis and interconversion (transamination)  REACT_238  
 
More information is available from:
 

Keywords

Biological process 
Amino-acid biosynthesis  definition   [KW-0028]
Proline biosynthesis  definition   [KW-0641]
Molecular function 
Kinase  definition   [KW-0418]
Oxidoreductase  definition   [KW-0560]
Transferase  definition   [KW-0808]
Technical term 
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]
 

Further external links