ALDH18A1 - Delta-1-pyrroline-5-carboxylate synthase - human protein (Function)
 
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ALDH18A1 »  Delta-1-pyrroline-5-carboxylate synthase  (P5CS)
 
Protein also known as:  Aldehyde dehydrogenase family 18 member A1.
Gene name:  ALDH18A1
Family names: In the N-terminal section Glutamate 5-kinase
In the C-terminal section Gamma-glutamyl phosphate reductase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Glutamate 5-kinase activitydefinition[GO:0004349]  
1
  • IDAUniProtKB
Glutamate-5-semialdehyde dehydrogenase activitydefinition[GO:0004350]  
1
  • IDAUniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
GO biological process 
Citrulline biosynthetic processdefinition[GO:0019240]  
1
  • IMPUniProtKB
Glutamate metabolic processdefinition[GO:0006536]  
1
  • IMPUniProtKB
L-proline biosynthetic processdefinition[GO:0055129]  
  • IEAUniPathway
Ornithine biosynthetic processdefinition[GO:0006592]  
1
  • IMPUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Phosphorylationdefinition[GO:0016310]  
  • IEAUniProtKB KW
Proline biosynthetic processdefinition[GO:0006561]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.2.11: ATP + L-glutamate ADP + L-glutamate 5-phosphate.  
2
  • CuratedUniProtKB
EC 1.2.1.41: L-glutamate 5-semialdehyde + phosphate + NADP(+) L-glutamyl 5-phosphate + NADPH.  
2
  • CuratedUniProtKB
It is regulated in the following manners
Isoform  Long   Is insensitive to ornithine inhibition. This is due to the two amino acid insert which abolishes feedback inhibition of P5CS activity by L-ornithine.  
1
  • CuratedUniProtKB
Isoform  Short   Is inhibited by L-ornithine with a Ki of approximately 0.25 mm.  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathways
According to KEGG, this protein belongs to the following pathways:
Arginine and proline metabolism  hsa00330+5832  
Metabolic pathways  hsa01100+5832  
According to Reactome, this protein belongs to the following pathway:
Amino acid synthesis and interconversion (transamination)  REACT_238  
 
More information is available from:
 

Keywords

Biological process 
Amino-acid biosynthesis  definition   [KW-0028]
Proline biosynthesis  definition   [KW-0641]
Molecular function 
Kinase  definition   [KW-0418]
Oxidoreductase  definition   [KW-0560]
Transferase  definition   [KW-0808]
Technical term 
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]
 

Further external links