AIF1 - Allograft inflammatory factor 1 - human protein (Function)
 
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Protein
Gene
References

 
AIF1 »  Allograft inflammatory factor 1  (AIF-1)
 
Protein also known as:  Ionized calcium-binding adapter molecule 1.
Gene name:  AIF1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 66 3
GENE REF ISO

Function

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Overview 
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.  
4
  • UniProtKB
GO molecular function 
Actin filament bindingdefinition[GO:0051015]  
2
  • UniProtKB
Calcium ion bindingdefinition[GO:0005509]  
1
  • UniProtKB
GO biological process 
Actin filament bundle assemblydefinition[GO:0051017]  
1
  • UniProtKB
Actin filament polymerizationdefinition[GO:0030041]  
1
  • UniProtKB
Cellular response to extracellular stimulusdefinition[GO:0031668] silver  
1
  • Ortholog Compara
Cellular response to hormone stimulusdefinition[GO:0032870] silver  
1
  • Ortholog Compara
Cellular response to hydroperoxidedefinition[GO:0071447] silver  
1
  • Ortholog Compara
Cellular response to interferon-gammadefinition[GO:0071346]  
2
  • UniProtKB
  • Ortholog Curator
Cellular response to morphinedefinition[GO:0071315] silver  
1
  • Ortholog Compara
Inflammatory responsedefinition[GO:0006954]  
2
  • UniProtKB
  • Ortholog Curator
Microglial cell activationdefinition[GO:0001774]  
1
  • UniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
1
  • Ortholog Compara
Negative regulation of gene expressiondefinition[GO:0010629] silver  
1
  • Ortholog Compara
Negative regulation of smooth muscle cell chemotaxisdefinition[GO:0071672]  
1
  • UniProtKB
Negative regulation of smooth muscle cell proliferationdefinition[GO:0048662]  
2
  • UniProtKB
Phagocytosis, engulfmentdefinition[GO:0006911]  
1
  • Ortholog Curator
Positive regulation of G1/S transition of mitotic cell cycledefinition[GO:1900087]  
2
  • UniProtKB
Positive regulation of monocyte chemotaxisdefinition[GO:0090026]  
1
  • UniProtKB
Positive regulation of muscle hyperplasiadefinition[GO:0014739] silver  
1
  • Ortholog Compara
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429] silver  
1
  • Ortholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934] silver  
1
  • Ortholog Compara
Positive regulation of smooth muscle cell chemotaxisdefinition[GO:0071673]  
1
  • UniProtKB
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
2
  • UniProtKB
Positive regulation of T cell migrationdefinition[GO:2000406]  
1
  • UniProtKB
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • UniProtKB
Rac protein signal transductiondefinition[GO:0016601]  
1
  • Ortholog Curator
Response to axon injurydefinition[GO:0048678] silver  
1
  • Ortholog Compara
Response to electrical stimulusdefinition[GO:0051602] silver  
1
  • Ortholog Compara
Ruffle assemblydefinition[GO:0097178]  
2
  • UniProtKB
  • Ortholog Curator
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AIF1
GenomeRNAi: 199
PRO: PR:P55008