AIF1 - Allograft inflammatory factor 1 - human protein (Function)
 
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Protein
Gene
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AIF1 »  Allograft inflammatory factor 1  (AIF-1)
 
Protein also known as:  Ionized calcium-binding adapter molecule 1.
Gene name:  AIF1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 62 3
GENE REF ISO

Function

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Overview 
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.  
3
  • CuratedUniProtKB
GO molecular function 
Actin filament bindingdefinition[GO:0051015]  
2
  • IDAUniProtKB
Calcium ion bindingdefinition[GO:0005509]  
1
  • ISSUniProtKB
GO biological process 
Actin filament bundle assemblydefinition[GO:0051017]  
1
  • IDAUniProtKB
Actin filament polymerizationdefinition[GO:0030041]  
1
  • IDAUniProtKB
Cellular response to interferon-gammadefinition[GO:0071346]  
1
  • IEPUniProtKB
  • ISSOrtholog Curator
Inflammatory responsedefinition[GO:0006954]  
1
  • NASUniProtKB
  • ISSOrtholog Curator
Microglial cell activationdefinition[GO:0001774]  
1
  • NASUniProtKB
Negative regulation of smooth muscle cell chemotaxisdefinition[GO:0071672]  
1
  • IDAUniProtKB
Negative regulation of smooth muscle cell proliferationdefinition[GO:0048662]  
2
  • IDAUniProtKB
Phagocytosis, engulfmentdefinition[GO:0006911]  
  • ISSOrtholog Curator
Positive regulation of G1/S transition of mitotic cell cycledefinition[GO:1900087]  
2
  • IDAUniProtKB
Positive regulation of monocyte chemotaxisdefinition[GO:0090026]  
1
  • IDAUniProtKB
Positive regulation of smooth muscle cell chemotaxisdefinition[GO:0071673]  
1
  • IDAUniProtKB
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
2
  • IDAUniProtKB
Positive regulation of T cell migrationdefinition[GO:2000406]  
1
  • IDAUniProtKB
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • IDAUniProtKB
Rac protein signal transductiondefinition[GO:0016601]  
  • ISSOrtholog Curator
Ruffle assemblydefinition[GO:0097178]  
1
  • NASUniProtKB
  • ISSOrtholog Curator
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AIF1
GenomeRNAi: 199
PRO: PR:P55008