SLC12A2 - Solute carrier family 12 member 2 - human protein (Function)
 
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SLC12A2 »  Solute carrier family 12 member 2
 
Protein also known as:  Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.
Gene name:  SLC12A2
Family name: SLC12A transporter
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 91 2
GENE REF ISO

Function

 show evidences
Overview 
Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the cation-chloride cotransporter (ccc) family  2.A.30.3.1  
GO molecular function 
Ammonium transmembrane transporter activitydefinition[GO:0008519]  
2
  • UniProtKB
Potassium ion symporter activitydefinition[GO:0022820]  
1
  • RefGenome
Potassium:chloride symporter activitydefinition[GO:0015379]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Sodium ion transmembrane transporter activitydefinition[GO:0015081]  
1
  • RefGenome
Sodium:chloride symporter activitydefinition[GO:0015378]  
1
  • RefGenome
Sodium:potassium:chloride symporter activitydefinition[GO:0008511]  
1
  • PINC
GO biological process 
Ammonium transmembrane transportdefinition[GO:0072488]  
2
  • GOC
Ammonium transportdefinition[GO:0015696]  
2
  • UniProtKB
Branching involved in mammary gland duct morphogenesisdefinition[GO:0060444] silver  
1
  • Ortholog Compara
Cell volume homeostasisdefinition[GO:0006884]  
1
  • RefGenome
Chloride ion homeostasisdefinition[GO:0055064]  
1
  • RefGenome
Chloride transmembrane transportdefinition[GO:1902476]  
3
  • GOC
  • RefGenome
  • InterPro 2 GO
Detection of mechanical stimulus involved in sensory perception of sounddefinition[GO:0050910] silver  
1
  • Ortholog Compara
Mammary duct terminal end bud growthdefinition[GO:0060763] silver  
1
  • Ortholog Compara
Multicellular organism growthdefinition[GO:0035264] silver  
1
  • Ortholog Compara
Potassium ion homeostasisdefinition[GO:0055075]  
1
  • RefGenome
Potassium ion importdefinition[GO:0010107]  
1
  • RefGenome
Sodium ion homeostasisdefinition[GO:0055078]  
1
  • RefGenome
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • RefGenome
Transepithelial ammonium transportdefinition[GO:0070634]  
1
  • UniProtKB
Transepithelial chloride transportdefinition[GO:0030321]  
1
  • UniProtKB
Transportdefinition[GO:0006810]  
1
  • PINC
Enzymatic activity 
It is regulated in the following manner
Activated by WNK3.  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Pancreatic secretion  hsa04972+6558  
Salivary secretion  hsa04970+6558  
Vibrio cholerae infection  hsa05110+6558  
According to Reactome, this protein belongs to the following pathway:
Cation-coupled Chloride cotransporters  R-HSA-426117  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Sodium transport  definition   [KW-0739]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 6558
PRO: PR:P55011
Chemistry
GuidetoPHARMACOLOGY: 969