SLC12A3 - Solute carrier family 12 member 3 - human protein (Function)
 
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SLC12A3 »  Solute carrier family 12 member 3
 
Protein also known as:  Thiazide-sensitive sodium-chloride cotransporter.
Gene name:  SLC12A3
Family name: SLC12A transporter
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 107 3
GENE REF ISO

Function

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Overview 
Key mediator of sodium and chloride reabsorption in this nephron segment, accounting for a significant fraction of renal sodium reabsorption.  
2
  • UniProtKB
According to TCDB this is a transporter from family:
the cation-chloride cotransporter (ccc) family  2.A.30.4.2  
GO molecular function 
Potassium ion symporter activitydefinition[GO:0022820]  
1
  • RefGenome
Potassium:chloride symporter activitydefinition[GO:0015379]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Sodium ion transmembrane transporter activitydefinition[GO:0015081]  
1
  • RefGenome
Sodium:chloride symporter activitydefinition[GO:0015378] silver  
1
  • Ortholog Compara
Sodium:potassium:chloride symporter activitydefinition[GO:0008511]  
1
  • RefGenome
Transporter activitydefinition[GO:0005215]  
1
  • Ortholog Curator
GO biological process 
Cell volume homeostasisdefinition[GO:0006884]  
1
  • RefGenome
Chloride ion homeostasisdefinition[GO:0055064]  
1
  • RefGenome
Chloride transmembrane transportdefinition[GO:1902476]  
4
  • GOC
  • InterPro 2 GO
  • RefGenome
  • Ortholog Compara
Potassium ion homeostasisdefinition[GO:0055075]  
1
  • RefGenome
Potassium ion importdefinition[GO:0010107]  
1
  • RefGenome
Sodium ion homeostasisdefinition[GO:0055078]  
1
  • RefGenome
Sodium ion transmembrane transportdefinition[GO:0035725]  
2
  • RefGenome
  • Ortholog Curator
Sodium ion transportdefinition[GO:0006814]  
1
  • Ortholog Curator
Transportdefinition[GO:0006810]  
2
  • PINC
Enzymatic activity 
It is regulated in the following manner
Activated by WNK3.  
2
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Cation-coupled Chloride cotransporters  R-HSA-426117  
Note 
Target of thiazide diuretics used in the treatment of high blood pressure.  
2
  • UniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Sodium-chloride_symporter
GenomeRNAi: 6559
PRO: PR:P55017
Chemistry
GuidetoPHARMACOLOGY: 970