NR1H2 - Oxysterols receptor LXR-beta - human protein (Function)
 
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NR1H2 »  Oxysterols receptor LXR-beta
 
Protein also known as:  Nuclear receptor subfamily 1 group H member 2.
Gene name:  NR1H2
Family name: Nuclear hormone receptor » NR1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 84 2
GENE REF ISO

Function

 show evidences
Overview 
Nuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Apolipoprotein A-I receptor bindingdefinition[GO:0034191]  
1
  • IPIBHF-UCL
ATPase bindingdefinition[GO:0051117]  
1
  • IPIBHF-UCL
DNA bindingdefinition[GO:0003677]  
1
  • TASPINC
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIHGNC
Retinoid X receptor bindingdefinition[GO:0046965] silver  
  • IEAOrtholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • IDANTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • IDANTNU_SB
Sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activitydefinition[GO:0001133] silver  
  • IEAOrtholog Compara
Steroid hormone receptor activitydefinition[GO:0003707] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cellular lipid metabolic processdefinition[GO:0044255] silver  
  • IEAOrtholog Compara
Cholesterol homeostasisdefinition[GO:0042632] silver  
  • IEAOrtholog Compara
Negative regulation of cholesterol storagedefinition[GO:0010887]  
1
  • IMPBHF-UCL
Negative regulation of interferon-gamma-mediated signaling pathwaydefinition[GO:0060336]  
1
  • NASBHF-UCL
Negative regulation of lipid transportdefinition[GO:0032369]  
1
  • IMPBHF-UCL
Negative regulation of macrophage derived foam cell differentiationdefinition[GO:0010745]  
1
  • ICBHF-UCL
Negative regulation of pinocytosisdefinition[GO:0048550]  
1
  • IMPBHF-UCL
Negative regulation of proteolysisdefinition[GO:0045861] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAHGNC
Positive regulation of cellular protein metabolic processdefinition[GO:0032270]  
1
  • IMPBHF-UCL
Positive regulation of cholesterol effluxdefinition[GO:0010875]  
1
  • IMPBHF-UCL
Positive regulation of cholesterol transportdefinition[GO:0032376]  
1
  • IDABHF-UCL
Positive regulation of fatty acid biosynthetic processdefinition[GO:0045723]  
1
  • IMPBHF-UCL
Positive regulation of high-density lipoprotein particle assemblydefinition[GO:0090108] silver  
  • IEAOrtholog Compara
Positive regulation of lipid storagedefinition[GO:0010884] silver  
  • IEAOrtholog Compara
Positive regulation of lipoprotein lipase activitydefinition[GO:0051006]  
1
  • IMPBHF-UCL
Positive regulation of pancreatic juice secretiondefinition[GO:0090187] silver  
  • IEAOrtholog Compara
Positive regulation of secretion of lysosomal enzymesdefinition[GO:0090340] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
4
  • IDAUniProtKB
  • IMPBHF-UCL
  • IDANTNU_SB
Positive regulation of triglyceride biosynthetic processdefinition[GO:0010867]  
1
  • IMPBHF-UCL
Regulation of cholesterol homeostasisdefinition[GO:2000188]  
  • ISSOrtholog Curator
Retinoic acid receptor signaling pathwaydefinition[GO:0048384] silver  
  • IEAOrtholog Compara
Steroid hormone mediated signaling pathwaydefinition[GO:0043401] silver  
  • IEAInterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathway:
Nuclear Receptor transcription pathway  REACT_15525  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Liver_X_receptor_beta
GenomeRNAi: 7376
PRO: PR:P55055
Chemistry
GuidetoPHARMACOLOGY: 601