AQP5 - Aquaporin-5 - human protein (Function)
 
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Protein
Gene
References

 
AQP5 »  Aquaporin-5  (AQP-5)
 
Gene name:  AQP5
Entry whose protein(s) existence is based on evidence at protein level
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1 79 1
GENE REF ISO

Function

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Overview 
Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed16571723).  
2
  • UniProtKB
According to TCDB this is a transporter from family:
the major intrinsic protein (mip) family  1.A.8.8.9  
GO molecular function 
Glycerol channel activitydefinition[GO:0015254]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
Water channel activitydefinition[GO:0015250]  
1
  • UniProtKB
GO biological process 
Camera-type eye morphogenesisdefinition[GO:0048593] silver  
1
  • Ortholog Compara
Carbon dioxide transportdefinition[GO:0015670]  
1
  • UniProtKB
Cellular water homeostasisdefinition[GO:0009992]  
1
  • RefGenome
Excretiondefinition[GO:0007588]  
1
  • PINC
Glycerol transportdefinition[GO:0015793]  
1
  • RefGenome
Ion transmembrane transportdefinition[GO:0034220]  
1
  • RefGenome
Odontogenesisdefinition[GO:0042476]  
1
  • UniProtKB
Pancreatic juice secretiondefinition[GO:0030157]  
1
  • UniProtKB
Saliva secretiondefinition[GO:0046541] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Salivary secretion  hsa04970+362  
According to Reactome, this protein belongs to the following pathway:
Passive transport by Aquaporins  R-HSA-432047  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: AQP5
GenomeRNAi: 362
PRO: PR:P55064
Chemistry
GuidetoPHARMACOLOGY: 692