VCP - Transitional endoplasmic reticulum ATPase - human protein (Function)
 
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VCP »  Transitional endoplasmic reticulum ATPase   [ EC 3.6.4.6 ]  (TER ATPase)
 
Protein also known as:  15S Mg(2+)-ATPase p97 subunit.
Gene name:  VCP
Family name: AAA ATPase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 216 1
GENE REF ISO

Function

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Overview 
Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.  
7
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the endoplasmic reticular retrotranslocon (er-rt) family  3.A.16.1.1  
GO molecular function 
ADP bindingdefinition[GO:0043531] silver  
  • IEAOrtholog Compara
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
ATPase activitydefinition[GO:0016887]  
1
  • TASUniProtKB
Identical protein bindingdefinition[GO:0042802] silver  
  • IEAOrtholog Compara
Lipid bindingdefinition[GO:0008289]  
  • IEAUniProtKB KW
Polyubiquitin bindingdefinition[GO:0031593]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
26
  • IPIUniProtKB
  • IPIIntAct
  • IPIBHF-UCL
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIUniProtKB
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • IPIBHF-UCL
Receptor bindingdefinition[GO:0005102] silver  
  • IEAOrtholog Compara
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
  • ISSOrtholog Curator
Aggresome assemblydefinition[GO:0070842] silver  
  • IEAOrtholog Compara
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
3
  • IDAUniProtKB
DNA repairdefinition[GO:0006281]  
1
  • NASUniProtKB
Double-strand break repairdefinition[GO:0006302]  
2
  • IDAUniProtKB
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968]  
1
  • TASUniProtKB
ER to Golgi vesicle-mediated transportdefinition[GO:0006888] silver  
  • IEAOrtholog Compara
ER-associated ubiquitin-dependent protein catabolic processdefinition[GO:0030433]  
2
  • IMPUniProtKB
Establishment of protein localizationdefinition[GO:0045184]  
1
  • TASUniProtKB
Positive regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032436]  
1
  • IDABHF-UCL
Positive regulation of protein catabolic processdefinition[GO:0045732]  
2
  • IDABHF-UCL
Positive regulation of protein complex assemblydefinition[GO:0031334]  
1
  • IDABHF-UCL
Proteasome-mediated ubiquitin-dependent protein catabolic processdefinition[GO:0043161]  
1
  • NASUniProtKB
Protein homooligomerizationdefinition[GO:0051260] silver  
  • IEAOrtholog Compara
Protein N-linked glycosylation via asparaginedefinition[GO:0018279]  
1
  • IMPUniProtKB
Protein ubiquitinationdefinition[GO:0016567]  
2
  • IDAUniProtKB
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • TASUniProtKB
Retrograde protein transport, ER to cytosoldefinition[GO:0030970]  
1
  • IDAUniProtKB
Translesion synthesisdefinition[GO:0019985]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.6: ATP + H(2)O ADP + phosphate.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Legionellosis  hsa05134+7415  
Protein processing in endoplasmic reticulum  hsa04141+7415  
Caution 
It is unclear how it participates in the recruitment of TP53BP1 at DNA damage sites. According to a first report, participates in the recruitment of TP53BP1 by promoting ubiquitination and removal of L3MBTL1 from DNA damage sites (PubMed22120668). According to a second report, it acts by removing 'Lys-48'-linked ubiquitination from sites of DNA damage (PubMed22020440).  
2
  • CuratedUniProtKB
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Transport  definition   [KW-0813]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Valosin-containing_protein
GenomeRNAi: 7415
PRO: PR:P55072