FGF8 - Fibroblast growth factor 8 - human protein (Function)
 
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Protein
Gene
References

 
FGF8 »  Fibroblast growth factor 8
 
Gene name:  FGF8
Entry whose protein(s) existence is based on evidence at protein level
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1 49 4
GENE REF ISO

Function

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Overview 
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.  
3
  • CuratedUniProtKB
GO molecular function 
Chemoattractant activitydefinition[GO:0042056] silver  
  • IEAOrtholog Compara
Fibroblast growth factor receptor bindingdefinition[GO:0005104] silver  
  • IEAInterPro 2 GO
Growth factor activitydefinition[GO:0008083]  
2
  • IDAUniProtKB
  • IEAUniProtKB KW
Isoform  FGF-8B   Type 1 fibroblast growth factor receptor bindingdefinition[GO:0005105]  
1
  • IDAUniProtKB
Isoform  FGF-8B   Type 2 fibroblast growth factor receptor bindingdefinition[GO:0005111]  
1
  • IDAUniProtKB
GO biological process 
Anatomical structure morphogenesisdefinition[GO:0009653]  
1
  • NASUniProtKB
Aorta morphogenesisdefinition[GO:0035909] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915] silver  
  • IEAOrtholog Compara
Blood vessel remodelingdefinition[GO:0001974] silver  
  • IEAOrtholog Compara
BMP signaling pathwaydefinition[GO:0030509] silver  
  • IEAOrtholog Compara
Bone developmentdefinition[GO:0060348]  
1
  • IMPUniProtKB
Branching involved in salivary gland morphogenesisdefinition[GO:0060445] silver  
  • IEAOrtholog Compara
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
  • IEAOrtholog Compara
Canonical Wnt signaling pathwaydefinition[GO:0060070] silver  
  • IEAOrtholog Compara
Cell migration involved in mesendoderm migrationdefinition[GO:0090134] silver  
  • IEAOrtholog Compara
Cell proliferation in forebraindefinition[GO:0021846] silver  
  • IEAOrtholog Compara
Corticotropin hormone secreting cell differentiationdefinition[GO:0060128] silver  
  • IEAOrtholog Compara
Dopaminergic neuron differentiationdefinition[GO:0071542]  
1
  • IDAUniProtKB
Dorsal/ventral axon guidancedefinition[GO:0033563] silver  
  • IEAOrtholog Compara
Embryonic hindlimb morphogenesisdefinition[GO:0035116] silver  
  • IEAOrtholog Compara
Epithelial to mesenchymal transition involved in endocardial cushion formationdefinition[GO:0003198]  
  • ISSOrtholog Curator
Fibroblast growth factor receptor signaling pathwaydefinition[GO:0008543]  
1
  • IGIMGI
Forebrain dorsal/ventral pattern formationdefinition[GO:0021798] silver  
  • IEAOrtholog Compara
Forebrain morphogenesisdefinition[GO:0048853] silver  
  • IEAOrtholog Compara
Forebrain neuron developmentdefinition[GO:0021884] silver  
  • IEAOrtholog Compara
Gastrulationdefinition[GO:0007369]  
1
  • NASUniProtKB
Gonad developmentdefinition[GO:0008406]  
1
  • IMPUniProtKB
Heart loopingdefinition[GO:0001947] silver  
  • IEAOrtholog Compara
Lung morphogenesisdefinition[GO:0060425] silver  
  • IEAOrtholog Compara
Male genitalia developmentdefinition[GO:0030539] silver  
  • IEAOrtholog Compara
MAPK cascadedefinition[GO:0000165] silver  
  • IEAOrtholog Compara
Mesodermal cell migrationdefinition[GO:0008078] silver  
  • IEAOrtholog Compara
Mesonephros developmentdefinition[GO:0001823]  
1
  • IEPUniProtKB
Metanephros developmentdefinition[GO:0001656]  
1
  • IEPUniProtKB
Midbrain-hindbrain boundary developmentdefinition[GO:0030917] silver  
  • IEAOrtholog Compara
Motor neuron axon guidancedefinition[GO:0008045] silver  
  • IEAOrtholog Compara
Negative regulation of cardiac muscle tissue developmentdefinition[GO:0055026]  
1
  • IMPBHF-UCL
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Neural plate morphogenesisdefinition[GO:0001839] silver  
  • IEAOrtholog Compara
Neuroepithelial cell differentiationdefinition[GO:0060563]  
1
  • IDAUniProtKB
Odontogenesisdefinition[GO:0042476]  
1
  • IEPUniProtKB
Organ inductiondefinition[GO:0001759] silver  
  • IEAOrtholog Compara
Otic vesicle formationdefinition[GO:0030916] silver  
  • IEAOrtholog Compara
Outflow tract septum morphogenesisdefinition[GO:0003148]  
  • ISSOrtholog Curator
Pallium developmentdefinition[GO:0021543] silver  
  • IEAOrtholog Compara
Patterning of blood vesselsdefinition[GO:0001569] silver  
  • IEAOrtholog Compara
Pharyngeal system developmentdefinition[GO:0060037] silver  
  • IEAOrtholog Compara
Positive chemotaxisdefinition[GO:0050918] silver  
  • IEAOrtholog Compara
Positive regulation of cell divisiondefinition[GO:0051781]  
  • IEAUniProtKB KW
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDAUniProtKB
  • IEAOrtholog Compara
Positive regulation of gene expressiondefinition[GO:0010628] silver  
  • IEAOrtholog Compara
Positive regulation of mitosisdefinition[GO:0045840] silver  
  • IEAOrtholog Compara
Positive regulation of organ growthdefinition[GO:0046622] silver  
  • IEAOrtholog Compara
Regulation of odontogenesis of dentin-containing toothdefinition[GO:0042487] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to organic cyclic compounddefinition[GO:0014070] silver  
  • IEAOrtholog Compara
Response to oxidative stressdefinition[GO:0006979] silver  
  • IEAOrtholog Compara
Signal transduction involved in regulation of gene expressiondefinition[GO:0023019] silver  
  • IEAOrtholog Compara
Subpallium developmentdefinition[GO:0021544] silver  
  • IEAOrtholog Compara
Thyroid gland developmentdefinition[GO:0030878] silver  
  • IEAOrtholog Compara
Thyroid-stimulating hormone-secreting cell differentiationdefinition[GO:0060129] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
MAPK signaling pathway  hsa04010+2253  
Melanoma  hsa05218+2253  
Pathways in cancer  hsa05200+2253  
Regulation of actin cytoskeleton  hsa04810+2253  
According to Reactome, this protein belongs to the following pathways:
Activated point mutants of FGFR2  REACT_120863  
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
FGFR1c ligand binding and activation  REACT_9515  
FGFR2c ligand binding and activation  REACT_9413  
FGFR3b ligand binding and activation  REACT_9508  
FGFR3c ligand binding and activation  REACT_9510  
FGFR4 ligand binding and activation  REACT_9452  
FRS2-mediated cascade  REACT_21247  
Negative regulation of FGFR signaling  REACT_111184  
Phospholipase C-mediated cascade  REACT_21310  
PI-3K cascade  REACT_21270  
PI3K Cascade  REACT_976  
PIP3 activates AKT signaling  REACT_75829  
SHC-mediated cascade  REACT_21374  
Signaling by activated point mutants of FGFR1  REACT_121153  
Signaling by activated point mutants of FGFR3  REACT_121337  
Signaling by FGFR mutants  REACT_121398  
Signaling by FGFR3 mutants  REACT_121249  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Mitogen  definition   [KW-0497]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FGF8
GenomeRNAi: 2253
PRO: PR:P55075