FGF8 - Fibroblast growth factor 8 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
FGF8 »  Fibroblast growth factor 8  (FGF-8)
 
Protein also known as:  Heparin-binding growth factor 8 (HBGF-8).
Gene name:  FGF8
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 50 4
GENE REF ISO

Function

 show evidences
Overview 
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.  
4
  • UniProtKB
GO molecular function 
Chemoattractant activitydefinition[GO:0042056] silver  
1
  • Ortholog Compara
Fibroblast growth factor receptor bindingdefinition[GO:0005104] silver  
1
  • InterPro 2 GO
Growth factor activitydefinition[GO:0008083]  
3
  • UniProtKB
  • UniProtKB KW
Isoform  FGF-8B   Type 1 fibroblast growth factor receptor bindingdefinition[GO:0005105]  
1
  • UniProtKB
Isoform  FGF-8B   Type 2 fibroblast growth factor receptor bindingdefinition[GO:0005111]  
1
  • UniProtKB
GO biological process 
Anatomical structure morphogenesisdefinition[GO:0009653]  
1
  • UniProtKB
Aorta morphogenesisdefinition[GO:0035909] silver  
1
  • Ortholog Compara
Apoptotic processdefinition[GO:0006915] silver  
1
  • Ortholog Compara
Blood vessel remodelingdefinition[GO:0001974] silver  
1
  • Ortholog Compara
BMP signaling pathwaydefinition[GO:0030509] silver  
1
  • Ortholog Compara
Bone developmentdefinition[GO:0060348]  
1
  • UniProtKB
Branching involved in salivary gland morphogenesisdefinition[GO:0060445] silver  
1
  • Ortholog Compara
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
1
  • Ortholog Compara
Canonical Wnt signaling pathwaydefinition[GO:0060070] silver  
1
  • Ortholog Compara
Cell migration involved in mesendoderm migrationdefinition[GO:0090134] silver  
1
  • Ortholog Compara
Cell proliferation in forebraindefinition[GO:0021846] silver  
1
  • Ortholog Compara
Corticotropin hormone secreting cell differentiationdefinition[GO:0060128] silver  
1
  • Ortholog Compara
Dopaminergic neuron differentiationdefinition[GO:0071542]  
1
  • UniProtKB
Dorsal/ventral axon guidancedefinition[GO:0033563] silver  
1
  • Ortholog Compara
Embryonic hindlimb morphogenesisdefinition[GO:0035116] silver  
1
  • Ortholog Compara
Epithelial to mesenchymal transition involved in endocardial cushion formationdefinition[GO:0003198]  
1
  • Ortholog Curator
Fibroblast growth factor receptor signaling pathwaydefinition[GO:0008543]  
1
  • MGI
Forebrain dorsal/ventral pattern formationdefinition[GO:0021798] silver  
1
  • Ortholog Compara
Forebrain morphogenesisdefinition[GO:0048853] silver  
1
  • Ortholog Compara
Forebrain neuron developmentdefinition[GO:0021884] silver  
1
  • Ortholog Compara
Gastrulationdefinition[GO:0007369]  
1
  • UniProtKB
Gonad developmentdefinition[GO:0008406]  
1
  • UniProtKB
Heart loopingdefinition[GO:0001947] silver  
1
  • Ortholog Compara
Lung morphogenesisdefinition[GO:0060425] silver  
1
  • Ortholog Compara
Male genitalia developmentdefinition[GO:0030539] silver  
1
  • Ortholog Compara
MAPK cascadedefinition[GO:0000165] silver  
1
  • Ortholog Compara
Mesodermal cell migrationdefinition[GO:0008078] silver  
1
  • Ortholog Compara
Mesonephros developmentdefinition[GO:0001823]  
1
  • UniProtKB
Metanephros developmentdefinition[GO:0001656]  
1
  • UniProtKB
Midbrain-hindbrain boundary developmentdefinition[GO:0030917] silver  
1
  • Ortholog Compara
Motor neuron axon guidancedefinition[GO:0008045] silver  
1
  • Ortholog Compara
Negative regulation of cardiac muscle tissue developmentdefinition[GO:0055026]  
1
  • BHF-UCL
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Neural plate morphogenesisdefinition[GO:0001839] silver  
1
  • Ortholog Compara
Neuroepithelial cell differentiationdefinition[GO:0060563]  
1
  • UniProtKB
Odontogenesisdefinition[GO:0042476]  
1
  • UniProtKB
Organ inductiondefinition[GO:0001759] silver  
1
  • Ortholog Compara
Otic vesicle formationdefinition[GO:0030916] silver  
1
  • Ortholog Compara
Outflow tract septum morphogenesisdefinition[GO:0003148]  
1
  • Ortholog Curator
Pallium developmentdefinition[GO:0021543] silver  
1
  • Ortholog Compara
Patterning of blood vesselsdefinition[GO:0001569] silver  
1
  • Ortholog Compara
Pharyngeal system developmentdefinition[GO:0060037] silver  
1
  • Ortholog Compara
Positive chemotaxisdefinition[GO:0050918] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • UniProtKB
  • Ortholog Compara
Positive regulation of gene expressiondefinition[GO:0010628] silver  
1
  • Ortholog Compara
Positive regulation of mitosisdefinition[GO:0045840] silver  
1
  • Ortholog Compara
Positive regulation of organ growthdefinition[GO:0046622] silver  
1
  • Ortholog Compara
Regulation of odontogenesis of dentin-containing toothdefinition[GO:0042487] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to organic cyclic compounddefinition[GO:0014070] silver  
1
  • Ortholog Compara
Response to oxidative stressdefinition[GO:0006979] silver  
1
  • Ortholog Compara
Signal transduction involved in regulation of gene expressiondefinition[GO:0023019] silver  
1
  • Ortholog Compara
Subpallium developmentdefinition[GO:0021544] silver  
1
  • Ortholog Compara
Thyroid gland developmentdefinition[GO:0030878] silver  
1
  • Ortholog Compara
Thyroid-stimulating hormone-secreting cell differentiationdefinition[GO:0060129] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
MAPK signaling pathway  hsa04010+2253  
Melanoma  hsa05218+2253  
Pathways in cancer  hsa05200+2253  
Regulation of actin cytoskeleton  hsa04810+2253  
According to Reactome, this protein belongs to the following pathways:
Activated point mutants of FGFR2  REACT_120863  
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
FGFR1c ligand binding and activation  REACT_9515  
FGFR2c ligand binding and activation  REACT_9413  
FGFR3b ligand binding and activation  REACT_9508  
FGFR3c ligand binding and activation  REACT_9510  
FGFR4 ligand binding and activation  REACT_9452  
FRS2-mediated cascade  REACT_21247  
Negative regulation of FGFR signaling  REACT_111184  
Phospholipase C-mediated cascade  REACT_21310  
PI-3K cascade  REACT_21270  
PI3K Cascade  REACT_976  
PIP3 activates AKT signaling  REACT_75829  
SHC-mediated cascade  REACT_21374  
Signaling by activated point mutants of FGFR1  REACT_121153  
Signaling by activated point mutants of FGFR3  REACT_121337  
Signaling by FGFR mutants  REACT_121398  
Signaling by FGFR3 mutants  REACT_121249  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Mitogen  definition   [KW-0497]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FGF8
GenomeRNAi: 2253
PRO: PR:P55075