AQP4 - Aquaporin-4 - human protein (Function)
 
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Protein
Gene
References

 
AQP4 »  Aquaporin-4  (AQP-4)
 
Protein also known as:  Mercurial-insensitive water channel (MIWC).
Gene name:  AQP4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the major intrinsic protein (mip) family  1.A.8.8.5  
GO molecular function 
Glycerol channel activitydefinition[GO:0015254]  
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  • RefGenome
Water channel activitydefinition[GO:0015250]  
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  • RefGenome
Water transmembrane transporter activitydefinition[GO:0005372]  
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  • PINC
GO biological process 
Cellular response to interferon-gammadefinition[GO:0071346]  
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  • UniProtKB
Cellular water homeostasisdefinition[GO:0009992]  
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  • RefGenome
Glycerol transportdefinition[GO:0015793]  
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  • RefGenome
Ion transmembrane transportdefinition[GO:0034220]  
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  • RefGenome
Multicellular organismal water homeostasisdefinition[GO:0050891]  
2
  • UniProtKB
Transportdefinition[GO:0006810]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+361  
Vasopressin-regulated water reabsorption  hsa04962+361  
According to Reactome, this protein belongs to the following pathways:
Passive transport by Aquaporins  R-HSA-432047  
Vasopressin regulates renal water homeostasis via Aquaporins  R-HSA-432040  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Aquaporin_4
GenomeRNAi: 361
PRO: PR:P55087