AQP4 - Aquaporin-4 - human protein (Function)
 
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AQP4 »  Aquaporin-4  (AQP-4)
 
Protein also known as:  Mercurial-insensitive water channel (MIWC).
Gene name:  AQP4
Entry whose protein(s) existence is based on evidence at protein level
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1 152 2
GENE REF ISO

Function

 show evidences
Overview 
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the major intrinsic protein (mip) family  1.A.8.8.5  
GO molecular function 
Porin activitydefinition[GO:0015288] silver  
  • IEAOrtholog Compara
Water transmembrane transporter activitydefinition[GO:0005372]  
1
  • TASPINC
GO biological process 
Carbon dioxide transportdefinition[GO:0015670] silver  
  • IEAOrtholog Compara
Cellular response to estradiol stimulusdefinition[GO:0071392] silver  
  • IEAOrtholog Compara
Cellular response to interferon-gammadefinition[GO:0071346]  
1
  • IDAUniProtKB
Excretiondefinition[GO:0007588]  
1
  • TASPINC
Female pregnancydefinition[GO:0007565] silver  
  • IEAOrtholog Compara
Hyperosmotic salinity responsedefinition[GO:0042538] silver  
  • IEAOrtholog Compara
Multicellular organismal water homeostasisdefinition[GO:0050891]  
2
  • IEPUniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Protein homooligomerizationdefinition[GO:0051260] silver  
  • IEAOrtholog Compara
Renal water absorptiondefinition[GO:0070295] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to radiationdefinition[GO:0009314] silver  
  • IEAOrtholog Compara
Sensory perception of sounddefinition[GO:0007605] silver  
  • IEAOrtholog Compara
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+361  
Vasopressin-regulated water reabsorption  hsa04962+361  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Aquaporin_4
GenomeRNAi: 361
PRO: PR:P55087