ELL - RNA polymerase II elongation factor ELL - human protein (Function)
 
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Protein
Gene
References

 
ELL »  RNA polymerase II elongation factor ELL
 
Protein also known as:  Eleven-nineteen lysine-rich leukemia protein.
Gene name:  ELL
Family name: ELL/occludin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.  
5
  • CuratedUniProtKB
GO molecular function 
Phosphatase bindingdefinition[GO:0019902]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Negative regulation of phosphatase activitydefinition[GO:0010923]  
1
  • IDAUniProtKB
Positive regulation of DNA-templated transcription, elongationdefinition[GO:0032786]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathways:
Formation of HIV elongation complex in the absence of HIV Tat  REACT_22201  
Formation of HIV-1 elongation complex containing HIV-1 Tat  REACT_6346  
HIV elongation arrest and recovery  REACT_6259  
Pausing and recovery of HIV elongation  REACT_6244  
Pausing and recovery of Tat-mediated HIV elongation  REACT_6143  
RNA Polymerase II Pre-transcription Events  REACT_22107  
RNA Polymerase II Transcription Elongation  REACT_833  
Tat-mediated elongation of the HIV-1 transcript  REACT_6162  
Tat-mediated HIV elongation arrest and recovery  REACT_6344  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ELL_(gene)
GenomeRNAi: 8178
PRO: PR:P55199