CASP7 - Caspase-7 - human protein (Function)
 
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CASP7 »  Caspase-7   [ EC 3.4.22.60 ]  (CASP-7)
 
Protein also known as:  ICE-like apoptotic protease 3 (ICE-LAP3). Cleaved into:  Caspase-7 subunit p11; Caspase-7 subunit p20.
Gene name:  CASP7
Family name: Peptidase C14A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 93 4
GENE REF ISO

Function

 show evidences
Overview 
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.  
  • CuratedUniProtKB
GO molecular function 
Aspartic-type endopeptidase activitydefinition[GO:0004190] silver  
  • IEAOrtholog Compara
Cysteine-type endopeptidase activitydefinition[GO:0004197] silver  
  • IBARefGenome
Cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0097153] silver  
  • IEAOrtholog Compara
Cysteine-type peptidase activitydefinition[GO:0008234]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Execution phase of apoptosisdefinition[GO:0097194] silver  
  • IBARefGenome
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
1
  • IDAUniProtKB
Release of cytochrome c from mitochondriadefinition[GO:0001836] silver  
  • IEAOrtholog Compara
Response to UVdefinition[GO:0009411] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.60: Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-|-.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by isatin sulfonamides.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+840  
Apoptosis  hsa04210+840  
Legionellosis  hsa05134+840  
Pertussis  hsa05133+840  
According to Reactome, this protein belongs to the following pathway:
Apoptosis  REACT_578  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Caspase_7
GenomeRNAi: 840
PRO: PR:P55210
Chemistry
GuidetoPHARMACOLOGY: 1623