CASP9 - Caspase-9 - human protein (Function)
 
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CASP9 »  Caspase-9   [ EC 3.4.22.62 ]  (CASP-9)
 
Protein also known as:  Apoptotic protease-activating factor 3 (APAF-3). Cleaved into:  Caspase-9 subunit p10; Caspase-9 subunit p35.
Gene name:  CASP9
Family name: Peptidase C14A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).  
1
  • UniProtKB
Isoform  Iso 2   Lacks activity is an dominant-negative inhibitor of caspase-9.  
1
  • UniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
1
  • PINC
Cysteine-type endopeptidase activity involved in apoptotic signaling pathwaydefinition[GO:0097199]  
1
  • RefGenome
Enzyme activator activitydefinition[GO:0008047]  
1
  • PINC
Peptidase activitydefinition[GO:0008233]  
1
  • MGI
Protein bindingdefinition[GO:0005515]  
19
  • IntAct
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • UniProtKB
SH3 domain bindingdefinition[GO:0017124]  
1
  • UniProtKB
GO biological process 
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB
Cellular response to dexamethasone stimulusdefinition[GO:0071549] silver  
1
  • Ortholog Compara
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • UniProtKB
Cellular response to UVdefinition[GO:0034644]  
1
  • UniProtKB
Glial cell apoptotic processdefinition[GO:0034349] silver  
1
  • Ortholog Compara
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630]  
1
  • UniProtKB
Platelet formationdefinition[GO:0030220]  
1
  • UniProtKB
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
1
  • Ortholog Compara
Regulation of response to DNA damage stimulusdefinition[GO:2001020]  
1
  • UniProtKB
Response to antibioticdefinition[GO:0046677] silver  
1
  • Ortholog Compara
Response to cobalt iondefinition[GO:0032025] silver  
1
  • Ortholog Compara
Response to estradioldefinition[GO:0032355] silver  
1
  • Ortholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
1
  • Ortholog Compara
Signal transduction in response to DNA damagedefinition[GO:0042770]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.62: Strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp-|-Xaa.  
2
  • UniProtKB
It is regulated in the following manner
Inhibited by the effector protein NleF that is produced by pathogenic E.coli; this inhibits apoptosis.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+842  
Amyotrophic lateral sclerosis (ALS)  hsa05014+842  
Apoptosis  hsa04210+842  
Colorectal cancer  hsa05210+842  
Endometrial cancer  hsa05213+842  
Huntington's disease  hsa05016+842  
Influenza A  hsa05164+842  
Legionellosis  hsa05134+842  
Non-small cell lung cancer  hsa05223+842  
p53 signaling pathway  hsa04115+842  
Pancreatic cancer  hsa05212+842  
Parkinson's disease  hsa05012+842  
Pathways in cancer  hsa05200+842  
Prostate cancer  hsa05215+842  
Small cell lung cancer  hsa05222+842  
Toxoplasmosis  hsa05145+842  
Tuberculosis  hsa05152+842  
VEGF signaling pathway  hsa04370+842  
Viral myocarditis  hsa05416+842  
According to Reactome, this protein belongs to the following pathways:
Activation of caspases through apoptosome-mediated cleavage  REACT_607  
AKT phosphorylates targets in the cytosol  REACT_12564  
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
Formation of apoptosome  REACT_89  
NOD1/2 Signaling Pathway  REACT_75776  
Role of DCC in regulating apoptosis  REACT_22128  
SMAC binds to IAPs  REACT_2190  
SMAC-mediated dissociation of IAP:caspase complexes  REACT_1767  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P55211
Other
GeneWiki: Caspase-9
GenomeRNAi: 842
PRO: PR:P55211
Chemistry
GuidetoPHARMACOLOGY: 1625