CASP6 - Caspase-6 - human protein (Function)
 
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CASP6 »  Caspase-6   [ EC 3.4.22.59 ]  (CASP-6)
 
Protein also known as:  Apoptotic protease Mch-2. Cleaved into:  Caspase-6 subunit p11; Caspase-6 subunit p18.
Gene name:  CASP6
Family name: Peptidase C14A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.  
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197] silver  
  • IBARefGenome
Cysteine-type peptidase activitydefinition[GO:0008234]  
1
  • TASPINC
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915] silver  
  • IBARefGenome
Epithelial cell differentiationdefinition[GO:0030855]  
1
  • IEPUniProtKB
Proteolysisdefinition[GO:0006508]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.59: Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-.  
  • CuratedUniProtKB
It is regulated in the following manner
Activation is suppressed by phosphorylation at Ser-257.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Apoptosis  hsa04210+839  
According to Reactome, this protein belongs to the following pathways:
Apoptotic cleavage of cellular proteins  REACT_107  
Breakdown of the nuclear lamina  REACT_13472  
Caspase-mediated cleavage of cytoskeletal proteins  REACT_13541  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Caspase_6
GenomeRNAi: 839
PRO: PR:P55212
Chemistry
GuidetoPHARMACOLOGY: 1622