ADK - Adenosine kinase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ADK »  Adenosine kinase   [ EC 2.7.1.20 ]  (AK)
 
Protein also known as:  Adenosine 5'-phosphotransferase.
Gene name:  ADK
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 28 4
GENE REF ISO

Function

 show evidences
Overview 
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Phosphotransferase activity, alcohol group as acceptordefinition[GO:0016773] silver  
  • IEAInterPro 2 GO
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
GO biological process 
Adenosine metabolic processdefinition[GO:0046085] silver  
  • IEAOrtholog Compara
AMP salvagedefinition[GO:0044209]  
  • IEAUniPathway
Circadian regulation of gene expressiondefinition[GO:0032922] silver  
  • IEAOrtholog Compara
dATP biosynthetic processdefinition[GO:0006175] silver  
  • IEAOrtholog Compara
Positive regulation of cardiac muscle hypertrophydefinition[GO:0010613] silver  
  • IEAOrtholog Compara
Positive regulation of T cell proliferationdefinition[GO:0042102] silver  
  • IEAOrtholog Compara
Purine ribonucleoside salvagedefinition[GO:0006166] silver  
  • IEAOrtholog Compara
Ribonucleoside monophosphate biosynthetic processdefinition[GO:0009156]  
1
  • TASPINC
Type B pancreatic cell proliferationdefinition[GO:0044342] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.1.20: ATP + adenosine ADP + AMP.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 3 magnesium ions per subunit.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+132  
Purine metabolism  hsa00230+132  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Purine salvage  definition   [KW-0660]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P55263
Other
GeneWiki: ADK_(gene)
GenomeRNAi: 132
PRO: PR:P55263
Chemistry
GuidetoPHARMACOLOGY: 1231